静电纺丝玉米醇溶蛋白纤维的制备及其在药物传递系统中的应用研究进展

发布时间：2018-07-07 11:47

本文选题：静电纺丝 + 玉米醇溶蛋白　；参考：《中国药房》2015年25期

【摘要】：目的:为制备静电纺丝玉米醇溶蛋白纤维(EZF)及其在药物传递系统中的应用提供参考。方法:以"玉米醇溶蛋白""静电纺丝""Zein""Electrostatic spinning""Drug delivery"等为关键词,查询2005-2015年中国知网、万方、Pub Med、Science Direct等数据库中关于EZF及其应用相关的文献,分别对EZF制备中溶剂的选用、喷丝口堵塞、改性方式及其在药物传递系统中的应用进行简述。结果与结论:共查到相关文献200余条,其中有效文献34条。EZF制备中常用溶剂有乙醇、三氟乙醇、二甲基甲酰胺、甲酸、乙酸等,其中以乙醇居多;溶剂蒸发过快是引起喷丝口堵塞的主要原因,常通过改进实验设备或同轴纺丝等方式解决;可采用共混改性、化学改性、塑化剂改性、同轴电纺改性等方法改善其机械性能;EZF主要用于延缓药物释放、提高易水解药物稳定性、实现联合包载、制备共混电纺纤维等。EZF虽具有生物相容性良好、可降解、尺寸可控等诸多优势,但必须提高其机械性能,以拓宽其在药剂学中的应用。
[Abstract]:Objective: to provide reference for the preparation of electrostatic spinning Zein fiber (EZF) and its application in drug delivery system. Methods: taking "Zein", "Zein", "Electrostatic spinning" Drug delivery "as the keywords, the literature on EZF and its application in the database of" Zein "," Zein "," Electrostatic spinning "and" Drug delivery "from 2005 to 2015 were investigated. The modification method and its application in drug delivery system were reviewed. Results & conclusion: more than 200 related documents were found, among which 34 effective ones were ethanol, trifluoroethanol, dimethylformamide, formic acid, acetic acid and so on. Ethanol was the most common solvent in the preparation of EZF. Too fast evaporation of solvent is the main cause of spinneret clogging, which is usually solved by improving the experimental equipment or coaxial spinning, which can be modified by blending modification, chemical modification, plasticizer modification, etc. The mechanical properties of EZF modified by coaxial electrospinning are mainly used to delay the release of drugs, improve the stability of hydrolysable drugs, realize the combined encapsulation, and prepare the blended electrospun fibers. EZF has good biocompatibility and biodegradability. It is necessary to improve its mechanical properties in order to expand its application in pharmacy.
【作者单位】：黑龙江中医药大学药学院;黑龙江民族职业学院;
【分类号】：R943

【参考文献】