武汉地区女性精神障碍患者呼吸道感染抗菌药物应用的调查

发布时间：2018-07-09 10:58

本文选题：精神障碍 + 女性　；参考：《中华医院感染学杂志》2015年12期

【摘要】：目的探讨武汉地区女性精神障碍患者呼吸道感染病原菌分布及其对抗菌药物的药敏性,为精神障碍患者呼吸道感染抗菌药物的临床应用提供参考。方法选取2013年4-10月武汉地区9所精神医院(科)收治的合并呼吸道感染女性精神障碍患者307例,采集患者呼吸道分泌物行病原菌培养和药物敏感试验,采用法国生物梅里埃公司ATB半自动细菌分析仪进行病原菌鉴定,并通过K-B纸片扩散法进行药物敏感试验,数据采用SPSS13.0软件进行统计分析。结果 307例患者送检痰液标本共检出病原菌293株,其中革兰阳性菌检出188株占64.16%,以金黄色葡萄球菌、肺炎链球菌及表皮葡萄球菌为主,分别占24.57%、21.50%和11.60%,革兰阴性菌检出102株占34.81%,真菌3株占1.03%;革兰阳性菌对万古霉素的敏感率均为100.00%,而对青霉素、磺胺甲VA唑/甲氧苄啶的敏感性较低,分别为11.17%和12.23%,革兰阴性菌对亚胺培南、头孢哌酮/舒巴坦和哌拉西林/他唑巴坦敏感率较高,分别达到98.04%、97.06%和94.12%;而对氨苄西林敏感率较低,仅为6.87%。结论女性精神障碍患者呼吸道感染病原菌丰富多样,而且不同类型的病原菌对抗菌药物的敏感性也不同,应根据药敏试验结果为患者选择针对性的敏感抗菌药物。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria and antimicrobial susceptibility of respiratory tract infection in patients with mental disorders in Wuhan area, and to provide reference for the clinical application of antimicrobial agents for respiratory infections in patients with mental disorders. Methods the patients with respiratory infection in 9 psychiatric hospitals in Wuhan area in 4-10 months of 2013 were selected to be treated with mental disorders in women with respiratory infection. In 307 cases, the pathogenic bacteria culture and drug sensitivity test were collected from the respiratory secretions of the patients. The pathogenic bacteria were identified by the ATB semi automatic bacterial analyzer of the French bioriri company, and the drug sensitivity test was carried out by the K-B paper diffusion method. The data were analyzed by SPSS13.0 software. The results of the sputum specimens were tested in 307 cases. 293 strains of pathogenic bacteria were detected, of which 188 strains were detected by Gram-positive bacteria, which were mainly Staphylococcus aureus, Streptococcus pneumoniae and Staphylococcus epidermidis, accounting for 24.57%, 21.50% and 11.60% respectively, Gram-negative bacteria were 34.81%, fungi 3 were 1.03%, and Gram-positive bacteria were susceptible to vancomycin by 100%, while penicillin and sulfonamides were found in Gram-positive bacteria. The sensitivity of methazole to methazole / trimethoprim was 11.17% and 12.23%, respectively. The sensitivity of Gram-negative bacteria to imipenem, Cefoperazone / Shubatan and piperacillin / tazobactam was higher, reaching 98.04%, 97.06% and 94.12%, respectively, while the sensitivity of ampicillin to ampicillin was low, only 6.87. Conclusion the pathogenic bacteria of respiratory tract infection in women with mental disorders were found. The sensitivity of the different types of pathogens to antimicrobial agents is different, and the sensitive antibiotics should be selected for the patients according to the results of drug sensitivity test.
【作者单位】：武汉市优抚医院精神科;
【基金】：湖北省卫生厅重点基金资助项目(HW-2010B034)
【分类号】：R969.3

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