耐碳青霉烯类抗生素肠杆菌科细菌耐药机制的研究进展

发布时间：2018-07-09 15:56

本文选题：耐碳青霉烯类肠杆菌科细菌 + 碳青霉烯酶　；参考：《国外医药(抗生素分册)》2016年02期

【摘要】：碳青霉烯类抗生素是一类含β-内酰胺结构的新型抗生素,具有广谱的抗菌活性,并且对β-内酰胺酶高度稳定。随着产超广谱β-内酰胺酶(Extended-Spectrumβ-Lactamases,ESBLs)的细菌越来越多,临床上常将碳青霉烯类药物作为ESBLs感染后的有效治疗方法,也因此增加了临床使用此类药物的频率。其直接结果就是导致耐碳青霉烯类抗生素菌株的产生,并且表现为泛耐药。早期报道的对碳青霉烯类耐药的细菌多是铜绿假单胞菌和鲍曼不动杆菌,但是近年来发现了越来越多的耐碳青霉烯类肠杆菌科细菌(Carbapenem-Resisitant Enterobacteriaceae,CRE)。这逐渐成为临床抗感染用药中的难题。因此,对细菌耐药机制进行研究,了解细菌的耐药性,以期待更好的指导临床使用抗生素。
[Abstract]:Carbapenem antibiotics are a new class of antibiotics with 尾-lactam structure, which have broad spectrum antibacterial activity and high stability to 尾-lactamases. With the increasing production of Extended-Spectrum 尾 -Lactamases ESBLs (ESBLs), carbapenem is often used as an effective method for the treatment of ESBLs infection, thus increasing the frequency of clinical use of these drugs. The direct result is the production of carbapenem-resistant antibiotic strains, which are shown to be pan-resistant. Pseudomonas aeruginosa and Acinetobacter baumannii have been reported to be resistant to carbapenem, but more and more carbapenem-resisitant Enterobacteriaceaeae (CRE) have been found in recent years. This has gradually become a difficult problem in clinical anti-infective drugs. Therefore, to study the mechanism of bacterial resistance, to understand the drug resistance of bacteria, in order to better guide the clinical use of antibiotics.
【作者单位】：鄂尔多斯市中心医院康巴什部检验科;
【基金】：鄂尔多斯市中心医院自主科研项目,项目编号:EY2014013
【分类号】：R978

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