氢溴酸高乌甲素纳米粒缓释片的制备

发布时间：2018-07-10 10:42

本文选题：氢溴酸高乌甲素 + 纳米粒　；参考：《中成药》2017年05期

【摘要】：目的制备氢溴酸高乌甲素纳米粒缓释片。方法高压乳匀法制备纳米粒,真空冷冻干燥后,将其与骨架缓释片辅料混匀,制备缓释凝胶骨架片。通过单因素试验考察吸附剂种类、羟丙基甲基纤维素(HPMC)类型及其用量、聚乙二醇(PEG)类型对释药行为的影响。结果最佳条件为以乳糖为吸附剂,HPMC 4K和HPMC 15M(比例1∶1)用量40 mg/片,PEG 400与PEG4000比例2∶1,所得缓释片的体外释放符合零级释药模型,12 h累积释放度达89.82%。结论该方法简单可靠,有利于工业化大批量生产氢溴酸高乌甲素纳米粒缓释片。
[Abstract]:Objective to prepare sustained release tablets of rapeconitine hydrobromide nanoparticles. Methods Nano-particles were prepared by high pressure emulsion method. After freeze-drying in vacuum, they were mixed with skeleton sustained-release tablets to prepare sustained-release gel matrix tablets. The effects of kinds of adsorbents, types and dosage of hydroxypropyl methyl cellulose (HPMC) and polyethylene glycol (PEG) on drug release behavior were investigated by single factor test. Results the optimum conditions were as follows: using lactose as adsorbent HPMC4K and HPMC15M (1:1), the ratio of PEG400 to PEG4000 was 2: 1. The release rate of the tablets in vitro was up to 89.82% in accordance with the zero-order drug release model. Conclusion the method is simple and reliable, which is beneficial to the production of buconiconitine hydrobromide nanocrystalline sustained release tablets.
【作者单位】：郑州澍青医学高等专科学校;中国医药工业研究总院上海医药工业研究院;
【分类号】：R943

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