辛苯聚醇温敏凝胶的制备及其体外释放研究
发布时间:2018-07-20 14:32
【摘要】:目的:制备辛苯聚醇阴道用温敏凝胶[(O-9)-VTG],并对其释放机制进行探讨。方法:采用冷溶法以泊洛沙姆407(P407)和泊洛沙姆188(P188)为温敏凝胶材料制备凝胶,倒置法测定其胶凝温度(TGEL),再应用星点设计-效应面法优化处方,并采用无膜溶出模型考察其体外溶蚀及释药情况。结果:优化的处方基质配比为P407∶P188∶甘油∶壳聚糖=16.3∶5.7∶5∶0.6,胶凝温度为33℃,胶凝时间约1.6 min;辛苯聚醇体外释放符合零级动力学方程。结论:效应面法筛选辛苯聚醇温敏凝胶处方合理,(O-9)-VTG作为新型阴道用避孕制剂前景良好。
[Abstract]:Aim: to prepare (O-9)-VTG for octylbenzene polyol vagina and to investigate its release mechanism. Methods: Poloxamer 407 (P407) and Poloxamer 188 (P188) were used as thermosensitive gels to prepare gels. The gelation temperature (TGEL) was determined by inversion method. The formulation was optimized by star design-effect surface method. The dissolution and drug release in vitro were investigated by using film-free dissolution model. Results: the optimized formulation matrix ratio was P407: P188: glycerol: chitosan: 16.3: 5.7: 5: 0.6, the gelation temperature was 33 鈩,
本文编号:2133842
[Abstract]:Aim: to prepare (O-9)-VTG for octylbenzene polyol vagina and to investigate its release mechanism. Methods: Poloxamer 407 (P407) and Poloxamer 188 (P188) were used as thermosensitive gels to prepare gels. The gelation temperature (TGEL) was determined by inversion method. The formulation was optimized by star design-effect surface method. The dissolution and drug release in vitro were investigated by using film-free dissolution model. Results: the optimized formulation matrix ratio was P407: P188: glycerol: chitosan: 16.3: 5.7: 5: 0.6, the gelation temperature was 33 鈩,
本文编号:2133842
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