微针阵列用于生物大分子药物的递送
发布时间：2018-07-25 16:29
【摘要】：生物大分子药物难以跨过皮肤的角质层屏障,而微针作为一种微创、无痛、高效的经皮给药方式,能有效破解大分子药物透皮速率和吸收量低下的难题.本文详细综述了微针阵列技术在各类生物大分子药物经皮递送中的应用进展,包括单独微针阵列(固体实心微针、空心微针、涂层微针和可溶性微针)以及微针与其他制剂技术(如微粒给药系统)、医疗器械和智能释药系统等结合对大分子药物的促渗作用和控释作用.同时对微针用于大分子药物递送领域目前面临的问题、发展前景等作出分析.
[Abstract]:It is difficult for biomolecules to cross the cuticle barrier of skin. As a minimally invasive painless and efficient transdermal delivery method microneedle can effectively solve the problem of low penetration rate and absorption of macromolecular drugs. In this paper, the application of microneedle array technology in the transdermal delivery of various biomolecules is reviewed in detail, including single microneedle array (solid microneedle, hollow microneedle, solid microneedle, hollow microneedle). Coating microneedles and soluble microneedles, and combination of microneedles with other preparation technologies (such as microparticle delivery systems), medical devices and intelligent drug delivery systems to promote the permeation and controlled release of macromolecular drugs. At the same time, the problems and development prospects of microneedles in the field of macromolecular drug delivery are analyzed.
【作者单位】： 浙江工业大学药学院生物制剂与材料实验室;
【基金】：浙江省重点科技创新团队项目(2013TD15)资助~~
【分类号】：R943
本文编号：2144395
[Abstract]:It is difficult for biomolecules to cross the cuticle barrier of skin. As a minimally invasive painless and efficient transdermal delivery method microneedle can effectively solve the problem of low penetration rate and absorption of macromolecular drugs. In this paper, the application of microneedle array technology in the transdermal delivery of various biomolecules is reviewed in detail, including single microneedle array (solid microneedle, hollow microneedle, solid microneedle, hollow microneedle). Coating microneedles and soluble microneedles, and combination of microneedles with other preparation technologies (such as microparticle delivery systems), medical devices and intelligent drug delivery systems to promote the permeation and controlled release of macromolecular drugs. At the same time, the problems and development prospects of microneedles in the field of macromolecular drug delivery are analyzed.
【作者单位】： 浙江工业大学药学院生物制剂与材料实验室;
【基金】：浙江省重点科技创新团队项目(2013TD15)资助~~
【分类号】：R943
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