纳米伊曲康唑药代动力学特性初步研究
发布时间：2018-08-02 14:52
【摘要】：伊曲康唑难溶于水,使其用药方式受到限制.以多聚物5k PEGCA8作为包裹物,采用薄膜分散法制备伊曲康唑纳米粒,静脉注射小鼠体内,采用荧光-HPLC测定血液和体内组织中伊曲康唑药物浓度,并通过药代动力学软件Win Nonlin测定纳米粒型伊曲康唑在小鼠体内的药代动力学特性.结果表明:小鼠血液最大浓度Cmax为(2.850±0.075)μg/L,血药浓度-时间曲线下面积AUC(0-∞)为(25 490.84±720.416)(μg·h)/L,半衰期t1/2z为(6.526±1.386)h,达锋时间Tmax为1h.研究结果表明,纳米型伊曲康唑可以有效解决伊曲康唑难溶于水的问题,为伊曲康唑注射针剂的开发提供了参考.
[Abstract]:Itraconazole is insoluble in water, limiting its drug use. Itraconazole nanoparticles were prepared by thin-film dispersion method with polymer 5k PEGCA8. The concentrations of itraconazole in blood and tissue were determined by fluorescence HPLC. The pharmacokinetics of itraconazole nanoparticles in mice was determined by pharmacokinetic software Win Nonlin. The results showed that the maximum blood concentration (Cmax) of mice was (2.850 卤0.075) 渭 g / L, the area under the plasma concentration-time curve (AUC _ 鈭，
本文编号：2159792
[Abstract]:Itraconazole is insoluble in water, limiting its drug use. Itraconazole nanoparticles were prepared by thin-film dispersion method with polymer 5k PEGCA8. The concentrations of itraconazole in blood and tissue were determined by fluorescence HPLC. The pharmacokinetics of itraconazole nanoparticles in mice was determined by pharmacokinetic software Win Nonlin. The results showed that the maximum blood concentration (Cmax) of mice was (2.850 卤0.075) 渭 g / L, the area under the plasma concentration-time curve (AUC _ 鈭，
本文编号：2159792
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2159792.html
最近更新
教材专著
