克服肿瘤生理病理屏障的纳米药物递送系统的研究进展

发布时间：2018-08-05 20:50

【摘要】：纳米药物递送系统在肿瘤的靶向治疗中发挥着越来越重要的作用。由于机体的生理特征以及肿瘤的异质性,递送系统从给药到靶点发挥作用需要克服多重生理及病理屏障,包括血液、肿瘤组织、细胞和胞内转运等屏障。本文综述了近年来为克服药物递送屏障提出的新思路与新方法,为设计克服肿瘤生理病理屏障的递送系统、实现对药物的有效递送和肿瘤的高效安全治疗提供理论参考。
[Abstract]:Nano-drug delivery system plays an increasingly important role in tumor targeting therapy. Due to the physiological characteristics of the body and the heterogeneity of tumor, the delivery system needs to overcome many physiological and pathological barriers, including blood, tumor tissue, cell and intracellular transport, from drug delivery to target. In this paper, new ideas and methods for overcoming drug delivery barriers are reviewed, and theoretical references are provided for the design of delivery systems for overcoming tumor physiological and pathological barriers and for the effective delivery of drugs and the effective and safe treatment of tumors.
【作者单位】：中国药科大学江苏省代谢性疾病药物重点实验室;
【基金】：国家自然科学基金资助项目(No.81473153,81273468)~~
【分类号】：R944

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