作用于肌肉型乙酰胆碱受体的生物毒素研究进展

发布时间：2018-08-06 16:14

【摘要】：目的近几十年,肌肉型乙酰胆碱受体(nicotinic acetylcholine receptors,nAChRs)成为神经生理学、药理学、药物设计及相关疾病研究的重要靶点。包括横纹肌肉瘤、小儿软组织瘤、肌源性紊乱等疾病都与肌肉型nAChRs的异常有关。因此寻找针对肌肉型nAChRs的特异性探针,对于研究受体的结构、功能及相关疾病发病机理与治疗药物研发至关重要。方法通过查阅相关文献对近年来发现的特异作用于肌肉型nAChRs的生物毒素进行了综述。结果与结论自然界中存在许多天然生物毒素,能特异作用于肌肉型nAChRs,这些毒素对于研究肌肉型nAChRs的结构和功能,以及相关疾病的诊断和治疗有着非常重要的应用价值。
[Abstract]:Objective in recent decades, muscle-type acetylcholine receptor (nicotinic acetylcholine receptor) has become an important target in neurophysiology, drug design and related diseases. Disorders such as rhabdomyosarcoma, soft tissue tumors in children, and myogenic disorders are all associated with abnormal muscular nAChRs. Therefore, it is very important to search for specific probes for muscle-type nAChRs in order to study the structure, function, pathogenesis of related diseases and the development of therapeutic drugs. Methods the biotoxins specific to muscular nAChRs were reviewed in recent years. Results and conclusion there are many natural biotoxins in nature, which can act specifically on muscle-type nAChRs. These toxins are of great value in the study of the structure and function of muscle-type nAChRs and in the diagnosis and treatment of related diseases.
【作者单位】：海南大学热带生物资源教育部重点实验室海口市海洋药物重点实验室;海南大学农学院;
【基金】：国家自然科学基金资助项目(41366002) 长江学者和创新团队发展计划资助项目(IRT_15R15)
【分类号】：R96

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