甲基苯丙胺微形态分析与毒理探讨

发布时间：2018-08-06 19:40

【摘要】：随着溶液理论的深入研究，溶剂化学引起了人们的广泛关注。从分子水平研究溶液的性质，例如离子-离子间缔合、离子-分子间溶剂化和溶剂的微观结构等，对现代生物化学发展具有巨大的指导意义，有助于溶液与生物环境中控制离子运动研究的发展，在溶液分子的空间结构、材料科学和生命科学研究等方面也有着重要的作用。本文在总结前人工作的基础上，以甲基苯丙胺-单溶剂和双溶剂溶液体系为研究对象，采用红外光谱、荧光光谱技术并结合理论计算方法考察分析了甲基苯丙胺在溶剂体系中的微观结构变化，讨论了其体内循环情况和中毒机理。主要研究内容如下： 1.采用荧光光谱技术研究了甲基苯丙胺的单溶剂、混合溶剂下的溶液体系的变化情况。通过对谱图中出现溶剂化新峰的分析和计算，讨论了溶液体系中的分子间相互弱作用力对物质微观形态的影响。 2.结合量子化学计算得到溶剂化结构的最优结构模型，讨论了甲基苯丙胺在单溶剂、双溶剂下微观形态的可能构型，并通过分析红外光谱验证了分子间化学键的变化，由此讨论了乙醇对甲基苯丙胺对人体循环的影响。 3.通过建立甲基苯丙胺诱导小鼠中毒模型，，研究了小鼠在体内循环后的分布情况，得出甲基苯丙胺广泛扩散于人体组织中，尤其以脑部最多。并通过理论计算从化学角度讨论了甲基苯丙胺的中毒机理。
[Abstract]:With the further study of solution theory, solvent chemistry has attracted wide attention. The study of the properties of solution at molecular level, such as ion-ion association, ion-intermolecular solvation and solvent microstructure, is of great significance for the development of modern biochemistry. It is helpful to the research of controlling ion movement in solution and biological environment and plays an important role in the study of spatial structure of solution molecules, material science and life science. In this paper, based on the previous work, the system of methamphetamine-single solvent and double solvent solution was used as the research object, and the infrared spectrum was used. The microstructural changes of methamphetamine in solvent system were investigated and analyzed by fluorescence spectroscopy and theoretical calculation. The internal circulation and poisoning mechanism of methamphetamine were discussed. The main contents are as follows: 1. The change of solution system of methamphetamine in single solvent and mixed solvent was studied by fluorescence spectroscopy. Based on the analysis and calculation of the solvation peak in the spectrum, the influence of the weak interaction between molecules in the solution system on the microstructure of the substance is discussed. 2. Combined with quantum chemical calculation, the optimal structure model of solvated structure was obtained. The possible configuration of the microstructure of methamphetamine in single and double solvents was discussed, and the change of intermolecular chemical bond was verified by IR spectra. The effect of ethanol on the circulation of methamphetamine was discussed. The distribution of methamphetamine in mice was studied by establishing a model of methamphetamine induced poisoning in vivo. It was concluded that methamphetamine spread widely in human tissues, especially in the brain. The mechanism of methamphetamine poisoning was discussed by theoretical calculation.
【学位授予单位】：合肥工业大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R917;O645.13

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