联合载体用于改善白藜芦醇固体分散体性能
发布时间：2018-08-07 07:08
【摘要】：通过载体聚乙烯吡咯烷酮(PVPk29/32)和羟丙基甲基纤维素(HPMC),采用溶剂法制备白藜芦醇(Res)二元及三元固体分散体。用傅里叶变换红外光谱(FTIR)、调制式差示扫描量热(MDSC)和X射线粉末衍射(XRD)等技术手段来表征Res二元和三元固体分散体并考察其溶出度。FTIR结果显示,Res与PVPk29/32及HPMC均存在氢键相互作用;溶出结果表明,二元和三元固体分散体均能提高药物的溶出度。而XRD和MDSC结果表明,三元固体分散体的相容性优于二元固体分散体;3个月的加速实验(40℃,75%RH(relative humidity))中,XRD、MDSC及体外溶出结果表明,Res三元固体分散体的稳定性优于Res二元固体分散体。HPMC的加入可以改善Res三元固体分散体的溶出及稳定性。
[Abstract]:The binary and ternary solid dispersions of resveratrol (Res) were prepared by solvent method using PVPk29/32 and (HPMC),. Fourier transform infrared spectroscopy (FTIR) (FTIR), modulated differential scanning calorimetry (MDSC) and X-ray powder diffraction (XRD) were used to characterize binary and ternary solid dispersion of Res. The dissolution results showed that both binary and ternary solid dispersions could improve the dissolution of the drug. XRD and MDSC results show that, The compatibility of ternary solid dispersion was superior to that of binary solid dispersion, and the results of three months accelerated experiment (40 鈩，
本文编号：2169260
[Abstract]:The binary and ternary solid dispersions of resveratrol (Res) were prepared by solvent method using PVPk29/32 and (HPMC),. Fourier transform infrared spectroscopy (FTIR) (FTIR), modulated differential scanning calorimetry (MDSC) and X-ray powder diffraction (XRD) were used to characterize binary and ternary solid dispersion of Res. The dissolution results showed that both binary and ternary solid dispersions could improve the dissolution of the drug. XRD and MDSC results show that, The compatibility of ternary solid dispersion was superior to that of binary solid dispersion, and the results of three months accelerated experiment (40 鈩，
本文编号：2169260
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2169260.html
最近更新
教材专著
