交联玻璃酸钠凝胶的制备及流变学研究
发布时间：2018-08-09 19:14
【摘要】：目的制备交联玻璃酸钠(CHA)凝胶并对其流变学性能进行考察。方法以1,4-丁二醇二缩水甘油醚(BDDE)为交联剂制备交联CHA,采用旋转流变仪测定玻璃酸钠(HA)和CHA的黏弹性及蠕变-恢复特性,考察不同浓度,不同交联度以及不同温度条件下,HA和CHA的流变学性能。结果本实验制备获得具有流动性的水不溶性CHA凝胶混悬液,并选择不锈钢平板(PU20)为夹具,振荡频率1 Hz、剪切应力1 Pa、温度(25±0.1)℃的条件测定其黏弹性。蠕变-恢复实验结果表明,对比HA,CHA形变量小,恢复至最小形变状态所用时间短,体系较稳定。结论 CHA属于假塑性非牛顿流体,符合其作为关节腔内黏弹性补充材料的性能要求,与非交联的HA相比,具有黏弹性高、热稳定性好的优点。
[Abstract]:Objective to prepare crosslinked sodium hyaluronate (CHA) gel and investigate its rheological properties. Methods crosslinked char was prepared by using 1-butanediol diglycidyl ether (BDDE) as crosslinking agent. Viscoelasticity and creep-recovery properties of (HA) and CHA were determined by rotating rheometer. Rheological properties of HA and CHA at different crosslinking degree and temperature. Results the aqueous insoluble CHA gel suspension with fluidity was prepared in this experiment. The viscoelasticity of the suspension was determined by using stainless steel plate (PU20) as clamp, oscillating frequency 1 Hz, shear stress 1 Paand temperature (25 卤0.1) 鈩，
本文编号：2175051
[Abstract]:Objective to prepare crosslinked sodium hyaluronate (CHA) gel and investigate its rheological properties. Methods crosslinked char was prepared by using 1-butanediol diglycidyl ether (BDDE) as crosslinking agent. Viscoelasticity and creep-recovery properties of (HA) and CHA were determined by rotating rheometer. Rheological properties of HA and CHA at different crosslinking degree and temperature. Results the aqueous insoluble CHA gel suspension with fluidity was prepared in this experiment. The viscoelasticity of the suspension was determined by using stainless steel plate (PU20) as clamp, oscillating frequency 1 Hz, shear stress 1 Paand temperature (25 卤0.1) 鈩，
本文编号：2175051
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