中空性纳米聚集颗粒用于肺部给药的研究进展

发布时间：2018-08-15 17:37

【摘要】：肺部给药是一种简单、直接、有效、无侵害性的给药方式,肺部药物递送可以达到局部及全身的治疗效果。纳米给药系统具有靶向及缓释特性,在提高治疗指数、降低不良反应方面具有显著优势。通过将纳米粒溶液或纳米粒和辅料的混合液进行喷雾干燥,可制得中空性纳米聚集颗粒。中空性纳米聚集颗粒具有较大几何直径和较小的密度,能够提高粒子的空气动力学直径,得到良好的肺部沉积率,是一种潜在的肺部纳米给药系统新剂型。本文从中空性纳米聚集颗粒的形成原理、影响因素、制备工艺等方面阐述了该新型制剂的关键技术,并对其物理化学性质、粉体动力学性质以及用于肺部给药的评价指标进行了总结,为该种新剂型应用于肺部给药的干粉吸入剂提供了制剂学参考。
[Abstract]:Pulmonary drug delivery is a simple, direct, effective and non-invasive drug delivery method. Pulmonary drug delivery can achieve local and systemic therapeutic effects. Nano-drug delivery system has the characteristics of targeting and slow release, and has significant advantages in improving the treatment index and reducing adverse reactions. Hollow nanoparticles can be prepared by spray drying of nanoparticles or mixtures of nanoparticles and excipients. Hollow nanoparticles have a large geometric diameter and a small density, which can improve the aerodynamics diameter of particles and obtain a good lung deposition rate. It is a potential new dosage form of pulmonary nano-drug delivery system. In this paper, the key technology of the new preparation is described from the forming principle, influencing factors and preparation process of the hollow nano-aggregate particles, and the physical and chemical properties of the new preparation are also discussed. The kinetic properties of the powder and the evaluation indexes used in pulmonary administration were summarized, which provided the preparation reference for the application of the new dosage form in lung administration of dry powder inhalants.
【作者单位】：北京大学药学院药剂学系;江汉大学医学院;
【分类号】：R943

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