聚乙二醇-聚乳酸-羟基乙酸嵌段共聚物载药纳米粒制备方法的研究进展

发布时间：2018-08-18 17:01

【摘要】：目的:为聚乙二醇-聚乳酸-羟基乙酸(PEG-PLGA)嵌段共聚物载药纳米粒制备方法的进一步研究提供参考。方法:以"聚乙二醇-聚乳酸-羟基乙酸""嵌段共聚物""载药纳米粒制备方法""PEG""PLGA""PEG-PLGA"等为关键词,组合查询1998年1月-2017年1月在Pub Med、Springer Link、Science Direct、中国知网、万方、维普等数据库中的相关文献,对溶剂挥发法、沉淀法、自乳化溶剂扩散法、盐析法等制备方法进行综述。结果与结论:共检索到相关文献246篇,其中有效文献28篇。虽然载药纳米粒制备方法已经解决了操作、耗能及环境污染上的一些难题,但仍然存在常使用毒性较大含氯有机溶剂和难以工业化大生产等问题。前者可通过寻找毒性较小的有机溶剂(如丙酮、乙酸乙酯)来代替和通过对PLGA结构修饰基团或合成方法的改进使其可溶于毒性较小的有机溶剂加以解决;后者可通过研发新型辅料,或是改进制备工艺(如冻干)来改善纳米粒的稳定性和研发新型生产设备来解决。
[Abstract]:Objective: to provide a reference for the preparation of poly (ethylene glycol)-poly (lactic acid)-glycolic acid (PEG-PLGA) block copolymer-loaded nanoparticles. Methods: taking "Polyethylene Glycol-Polylactic Acid-glycolic Acid" Block Copolymer "," preparation method of Drug-loaded nanoparticles "," PEG "," PLGA "PEG-PLGA" as keywords, a combination query was made at Pub MedSpringer LinkLinkLink Direct, China, Wanfang from January 1998 to January 2017. The preparation methods of solvent volatilization, precipitation, self-emulsifying solvent diffusion and salting out were reviewed. Results & conclusion: 246 related literatures were retrieved, of which 28 were valid. Although the preparation method of drug-loaded nanoparticles has solved some problems in operation, energy consumption and environmental pollution, there are still some problems such as the common use of toxic organic solvents containing chlorine and the difficulty of industrial production and so on. The former can be replaced by looking for less toxic organic solvents (such as acetone, ethyl acetate) and the solution can be solved by modifying the structure of PLGA or by improving the synthetic method so that it can be dissolved in less toxic organic solvents. The latter can be solved by developing new excipients or by improving the preparation process (such as freeze-drying) to improve the stability of nanoparticles and to develop new production equipment.
【作者单位】：黑龙江中医药大学药学院;黑龙江民族职业学院生物科技系;
【分类号】：R943

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