我院1005例药品不良反应报告分析

发布时间：2018-09-03 07:04

【摘要】：目的:了解我院药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:收集我院2005年1月-2014年8月上报国家ADR监测中心的ADR报告1 005例,采用回顾性分析方法对性别、年龄、药品种类、剂型分布、累及器官/系统、临床症状等进行统计。结果:10年来上报的ADR报告中,男、女分别占46.27%、53.73%。45岁以上严重的ADR发生率增加明显(占83.33%)。注射剂比其他剂型更容易引发ADR(占51.69%)。最常见的一般的ADR是轻中度的变态反应。最主要的严重的ADR是胃肠道出血、过敏性休克和肝功能损害,口服的非甾体抗炎药是引起胃肠道系统损害和肝胆系统损害最常见的药物。此外,护士对ADR上报工作参与度不够。结论:医护人员对中老年人用药应该特别注意ADR的发生,注射剂首先应注意其变态反应,应避免大剂量和/或长时间使用非甾体抗炎药,此外还应加强护士上报ADR的培训。
[Abstract]:Objective: to understand the characteristics and regularity of adverse drug reaction (ADR) in our hospital and to provide reference for rational drug use. Methods: 1 005 cases of ADR reported to the National ADR Surveillance Center from January 2005 to August 2014 were collected and analyzed retrospectively on sex, age, drug type, dosage form distribution, involvement of organs / systems, clinical symptoms and so on. Results: among the ADR reports reported in the past 10 years, the incidence of severe ADR increased significantly (83.33%) in men and women (46.27%) and 53.73% (83.33%) respectively. Injection was more likely to trigger ADR than other formulations (51.69%). The most common ADR is mild to moderate allergy. The most serious ADR is gastrointestinal bleeding, anaphylactic shock and liver function damage. Oral NSAIDs are the most common drugs to cause gastrointestinal system damage and hepatobiliary system damage. In addition, nurses did not participate enough in ADR reporting. Conclusion: medical staff should pay special attention to the occurrence of ADR and the allergic reaction of injection should be paid more attention to. The high dose and / or long term use of NSAIDs should be avoided. In addition, the training of nurses to report ADR should be strengthened.
【作者单位】：复旦大学附属金山医院;
【分类号】：R95

【参考文献】