以p73为靶点的抗肿瘤药物研究进展
发布时间：2018-09-08 08:07
【摘要】：肿瘤抑制因子p73可转录形成具有促凋亡(TAp73)和抗凋亡(△Np73)功能的2种亚型。但是,在肿瘤进程中,TAp73-负调节因子(如△Np73、突变p53、MDM2和iASPP)复合体的形成会阻碍TAp73的肿瘤抑制活性。因此,通过靶向抑制负调节因子或破坏TAp73-负调节因子复合体,释放出TAp73,进而达到抑制肿瘤的目的。该文就p73的靶向调控及相关药物的研究进展进行综述。
[Abstract]:Tumor suppressor p73 can be transcribed into two subtypes with the function of promoting apoptosis (TAp73) and anti apoptosis (Np73). However, the formation of TAp73- negative regulatory factor complexes (such as Np73, mutation p53 MDM2 and iASPP) in tumor progression may hinder the tumor inhibitory activity of TAp73. Therefore, TAp73, can be released by targeting negative regulatory factor or destroying TAp73- negative regulatory factor complex. In this paper, the target regulation of p73 and the research progress of related drugs are reviewed.
【作者单位】： 昆明理工大学医学院衰老与肿瘤分子遗传学实验室;
【基金】：国家自然科学基金资助项目(No 81560601) 昆明理工大学分析测试基金项目(No 2016M2014236022)
【分类号】：R979.1
，
本文编号：2229910
[Abstract]:Tumor suppressor p73 can be transcribed into two subtypes with the function of promoting apoptosis (TAp73) and anti apoptosis (Np73). However, the formation of TAp73- negative regulatory factor complexes (such as Np73, mutation p53 MDM2 and iASPP) in tumor progression may hinder the tumor inhibitory activity of TAp73. Therefore, TAp73, can be released by targeting negative regulatory factor or destroying TAp73- negative regulatory factor complex. In this paper, the target regulation of p73 and the research progress of related drugs are reviewed.
【作者单位】： 昆明理工大学医学院衰老与肿瘤分子遗传学实验室;
【基金】：国家自然科学基金资助项目(No 81560601) 昆明理工大学分析测试基金项目(No 2016M2014236022)
【分类号】：R979.1
，
本文编号：2229910
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2229910.html
最近更新
教材专著
