老年人应用辛伐他汀安全性的系统评价

发布时间：2018-09-08 19:11

【摘要】：目的系统评价辛伐他汀用于老年人的安全性。方法计算机检索Pub Med、EMBASE、Cochrane Library、CBM、CNKI、VIP和万方数据库,检索时间均从建库至2014年10月。获得老年人辛伐他汀安全性评价的随机对照试验(RCT)研究和病例报告。RCT文献采用Rev-Man 5.1软件进行Meta分析,余文献采用描述性分析。结果检出符合纳入标准的RCT文献45篇,病例报告27篇。(1)RCT文献结果:老年患者使用辛伐他汀的不良反应包括胃肠道反应、皮疹、肝脏转氨酶升高、肌肉骨骼系统不良反应和神经系统不良反应。辛伐他汀60 mg肝脏转氨酶升高发生率明显高于辛伐他汀20 mg,差异有统计学意义(P0.05),10 mg与20 mg、20 mg与40 mg辛伐他汀以及辛伐他汀与其他他汀类药物的胃肠道反应、神经系统不良反应和皮疹等发生率差异均无统计学意义(P0.05)。(2)病例报告分析结果:11例确定为辛伐他汀导致的不良反应,14例很有可能,5例可能。结论老年患者使用辛伐他汀的不良反应发生率低,安全性较好,但与某些药物存在不良相互作用,需关注其相互作用,开展进一步研究。
[Abstract]:Objective to evaluate the safety of simvastatin in the elderly. Methods Pub Med,EMBASE,Cochrane Library,CBM,CNKI,VIP and Wanfang databases were searched by computer and the retrieval time was from construction to October 2014. A randomized controlled trial (RCT) study and case report on the safety evaluation of simvastatin in the elderly were obtained. Meta analysis was performed by Rev-Man 5.1 software and descriptive analysis was used in the rest of the literature. Results 45 RCT papers and 27 case reports were detected. (1) the adverse effects of simvastatin use in elderly patients included gastrointestinal reactions, rash, and elevated liver transaminase. Musculoskeletal system adverse reactions and nervous system adverse reactions. The incidence of hepatic transaminase elevation in simvastatin at 60 mg was significantly higher than that in simvastatin for 20 mg, (P0.05). The gastrointestinal reactions of simvastatin and simvastatin with other statins were significantly higher than those of simvastatin for 10 mg and 20 mg,20 mg and 40 mg, respectively. There was no significant difference in the incidence of adverse reactions and rashes in nervous system (P0.05). (2). The results of analysis of 11 cases confirmed that 14 cases were identified as adverse reactions caused by simvastatin. 5 cases were likely to have adverse reactions caused by simvastatin (P0.05). (2). Conclusion the incidence of adverse effects of simvastatin is low and the safety is good, but there are some adverse interactions with some drugs, which need to be paid attention to and further studied.
【作者单位】：石河子大学药学院;石河子大学医学院第一附属医院药剂科;四川大学华西药学院;
【分类号】：R972

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