727例银杏达莫注射液不良反应报告分析

发布时间：2018-09-13 11:20

【摘要】：目的:了解银杏达莫注射液不良反应(ADR)发生的特点和一般规律,为临床合理用药提供参考。方法:以"银杏达莫注射液""不良反应"为主题词,检索中国学术期刊全文数据库2005年1月1日-2016年6月28日收载的期刊文献,对患者性别、年龄、原患疾病、过敏史、用药情况、ADR发生时间、累及器官/系统及临床表现等进行统计、分析。结果:检索得到有效文献14篇,共计727例患者。其中,女性多于男性(57.63%vs.42.37%),年龄多在50岁以上,原患疾病以血栓栓塞性疾病、冠心病为主;ADR多在用药30 min内发生(268例,36.86%);累及器官/系统以神经系统(254例,28.60%)、皮肤及其附件(228例,25.68%)和消化系统(187例,21.06%)为主,严重者可致过敏性休克;新的严重的ADR 18例(2.48%);所有ADR均好转,无死亡病例。结论:临床应严格掌握银杏达莫注射液的适应证,辨证施治、合理用药,对用药过程严密观察,警惕ADR的发生。
[Abstract]:Objective: to investigate the characteristics and general rules of adverse reactions of Ginkgo biloba injection (Ginkgo biloba injection) in (ADR), and to provide reference for rational drug use. Methods: using "Ginkgo biloba injection" and "adverse reaction" as the theme words, the Chinese academic Journal Full-text Database was used to search the literature collected from January 1, 2005 to June 28, 2016. The occurrence time of ADR, the involvement of organs / systems and clinical manifestations were analyzed. Results: a total of 727 patients were found in 14 effective literatures. Among them, women were more than men (57.63 vs. 42.37%), most of them were over 50 years old, and the original diseases were thromboembolic diseases. The main causes of coronary heart disease (CHD) were found within 30 min (268 cases, 36.86%), involving the nervous system (254 cases, 28.60%), the skin and its appendages (228 cases, 25.68%) and the digestive system (187 cases, 21.06%). There were 18 cases (2.48%) of new severe ADR, all ADR were improved and there were no death cases. Conclusion: the indications of Ginkgo biloba injection should be strictly grasped, treated by differentiation of symptoms and signs, used rationally, the course of medication should be observed closely and the occurrence of ADR should be guarded.
【作者单位】：重庆市急救医疗中心保健科;重庆市急救医疗中心药剂科;重庆市急救医疗中心创伤科;重庆市急救医疗中心重症监护病房;
【分类号】：R95

【相似文献】