金属螯合物8-羟基喹啉及其衍生物的药理作用研究概况

发布时间：2018-09-13 13:23

【摘要】：目的:了解金属螯合物8-羟基喹啉(8HQ)及其衍生物的药理作用,为具有多种药理活性的新药研发奠定基础。方法:以"8-羟基喹啉""金属螯合物""药理作用""8HQ""Metal chelate""Pharmacological effects"等为关键词,组合查询Pub Med、谷歌学术及Elsevier电子期刊等数据库中2000年1月至2015年1月的有关文献,对8HQ及其衍生物的药理作用进行综述。结果与结论:共查阅到相关文献105篇,其中有效文献30篇。研究表明,8HQ及其衍生物在体内与金属离子螯合并可表现出多种药理作用,如治疗神经退行性疾病、抗肿瘤、抗微生物、抗氧化及抗糖尿病等;其研究与应用前景广阔,可为寻找高效、低毒、具有多种明显药理作用的新型桥联配合物提供化学物质基础。
[Abstract]:Aim: to investigate the pharmacological effects of metal chelate 8-hydroxyquinoline (8HQ) and its derivatives, and to establish a foundation for the development of new drugs with various pharmacological activities. Methods: taking "8-hydroxyquinoline", "metal chelate", "pharmacological action", "8HQ", "Metal chelate", "Pharmacological effects" as keywords, the relevant literatures of Pub Med, Google academic and Elsevier electronic journals were searched for from January 2000 to January 2015. The pharmacological effects of 8HQ and its derivatives were reviewed. Results & conclusion: 105 articles were reviewed, 30 of which were valid. It has been shown that the chelate of HY8HQ and its derivatives in vivo can exhibit many pharmacological effects, such as the treatment of neurodegenerative diseases, anti-tumor, anti-microbial, anti-oxidation and anti-diabetes, etc. It can provide chemical basis for finding novel bridging complexes with high efficiency, low toxicity and many obvious pharmacological effects.
【作者单位】：泰安市第一人民医院;济南再生医学与转化医学研究院;
【分类号】：R96

【共引文献】