我院万古霉素临床合理使用评价及血药浓度监测分析

发布时间：2018-09-14 19:33

【摘要】：目的:为万古霉素临床合理使用提供参考。方法:收集我院2015年1月-2016年6月使用万古霉素的299例患者的病历资料,对用药情况、用药合理性、病原学检查结果、万古霉素血药浓度、疗效、不良反应等指标进行统计分析。结果:我院住院患者应用万古霉素多为治疗用药,且以经验性治疗用药为主(90.30%);用药前样本送检率为61.82%,有52例(28.42%)患者检出特异病原菌。万古霉素用药不合理的有69例(23.08%),均为药物浓度不适宜。万古霉素血药浓度监测率为43.33%,谷浓度维持在10~20mg/L的占40.00%;治疗有效率为79.39%;治疗后急性肾损伤的发生率为5.41%。结论:我院住院患者应用万古霉素前样本送检率和血药浓度监测率均偏低,有效血药谷浓度的患者比例亦低。医院应加强万古霉素的应用管理,促进临床个体化用药。
[Abstract]:Objective: to provide reference for the rational use of vancomycin in clinic. Methods: the medical records of 299 patients with vancomycin used in our hospital from January 2015 to June 2016 were collected. Adverse reactions and other indicators were statistically analyzed. Results: in our hospital, vancomycin was mostly used as therapeutic drug, and empirical therapy was the main drug (90.30%), and the rate of sample examination was 61.82%, 52 cases (28.42%) were detected specific pathogenic bacteria. There were 69 cases (23.08%) with unreasonable vancomycin, all of which were unsuitable for drug concentration. The monitoring rate of vancomycin concentration in blood was 43.33, the percentage of valley concentration in 10~20mg/L was 40.00g, the effective rate was 79.39, and the incidence of acute renal injury after treatment was 5.41%. Conclusion: before the use of vancomycin in our hospital, the sampling rate and the monitoring rate of blood drug concentration were low, and the proportion of patients with effective blood drug concentration was also low. Hospital should strengthen the application management of vancomycin and promote clinical individualized drug use.
【作者单位】：南京医科大学第一附属医院药学部;
【基金】：江苏高校优势学科建设工程一期项目
【分类号】：R978.1

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