临床药师干预前后苄星青霉素致严重不良反应的实例分析

发布时间：2018-09-16 20:43

【摘要】：目的:探讨临床药师参与药品不良反应(ADR)监测及干预的效果。方法:分析2012年11月-2013年4月我院门诊上报的11例早期梅毒患者肌肉注射苄星青霉素后引起过敏性休克严重ADR的报告,按照临床药师干预前后进行分组。干预措施包括严格规范青霉素皮试液的配制、关注药品生产批号并及时上报和更换不同批号药品、严格按药品说明书用药。比较干预前后的严重ADR发生率及患者的治愈效果。结果:经临床药师干预后,半年内我院门诊注射用苄星青霉素引起严重ADR的发生率呈明显下降趋势;干预前后患者的临床治愈率均良好(100%)(P0.05),血清学转阴率分别为66.49%、60.00%(P0.05)。结论:临床药师实施ADR监测,及时干预治疗,可明显降低ADR的发生率。
[Abstract]:Objective: to investigate the effect of clinical pharmacists on (ADR) monitoring and intervention of adverse drug reactions. Methods: from November 2012 to April 2013, 11 patients with early syphilis who were treated with benzylpenicillin intramuscularly after injection of benzylpenicillin were analyzed. The reports of severe ADR induced by anaphylactic shock were analyzed and divided into groups before and after intervention by clinical pharmacists. The intervention measures include strictly standardizing the preparation of penicillin skin test fluid, paying attention to the batch number of drug production and timely reporting and replacing different batches of drugs, strictly according to the drug instructions. The incidence of severe ADR and the curative effect of the patients were compared before and after intervention. Results: after intervention by clinical pharmacists, the incidence of severe ADR caused by benzylpenicillin for injection in outpatient department of our hospital decreased significantly within six months, the clinical cure rate of patients before and after intervention was 100% (P0.05), and the serological negative rate was 66.49g / 60.00% (P0.05). Conclusion: clinical pharmacists can significantly reduce the incidence of ADR by monitoring ADR and intervening in time.
【作者单位】：解放军第180医院;
【分类号】：R969.3

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