胸外科围术期抗菌药物使用全程持续干预的效果评价

发布时间：2018-09-17 09:03

【摘要】：目的:评价临床药师在胸外科围术期抗菌药物合理使用全程持续干预的效果。方法:收集广州医科大学附属肿瘤医院2012年1-12月(干预前)、2013年7月-2014年6月(干预后)胸外科行手术治疗的患者病历,各300例。对干预前后抗菌药物使用种类以及使用频率、联合用药情况、人均抗菌药物使用时间以及种类、人均抗菌药物费用占住院费用比例,以及抗菌药物使用合理性进行比较。结果:干预后患者抗菌药物使用种类较干预前少,且第一代头孢菌素类药物使用比例明显升高,差异有统计学意义(P0.05);干预前患者围术期抗菌药物单用比例为74.00%、联用比例为26.00%,干预后患者围术期抗菌药物单用比例为97.37%、联用比例为2.63%,干预前后比较差异有统计学意义(P0.05);干预后患者人均抗菌药物使用时间、人均抗菌药物使用种类以及人均抗菌药物费用占住院费用比例均明显低于干预前,干预后抗菌药物使用合理性明显高于干预前,差异均有统计学意义(P0.05)。结论:临床药师在胸外科围术期抗菌药物使用中全程持续干预可明显提高抗菌药物临床使用合理性,减少抗菌药物临床使用量,降低患者医疗费用,提升临床医疗服务质量。
[Abstract]:Objective: to evaluate the effect of rational use of antibiotics in thoracic surgery. Methods: the medical records of 300 cases of thoracic surgery were collected from January to December 2012 (before intervention) and from July 2013 to June 2014 (after intervention) in Cancer Hospital affiliated to Guangzhou Medical University. The types and frequency of antimicrobial use before and after intervention, the situation of combined use, the time and type of antimicrobial use per capita, the proportion of per capita cost of antimicrobial agents to hospital expenses, and the rationality of the use of antimicrobial agents were compared before and after intervention. Results: after intervention, the kinds of antimicrobial drugs used in patients were fewer than those before intervention, and the proportion of cephalosporins used in the first generation was obviously increased. The difference was statistically significant (P0.05), the proportion of single use of antibiotics before intervention was 74.00 and the proportion of combined use was 26.00. After intervention, the proportion of single use of antibiotics in perioperative period was 97.37, and the proportion of combined use was 2.63.The difference before and after intervention was statistically significant. Mean (P0.05); time of use of antimicrobial agents per patient after intervention, The types of antimicrobial use per capita and the proportion of per capita antimicrobial expenses in hospital expenses were significantly lower than those before intervention, and the rationality of antimicrobial use after intervention was significantly higher than that before intervention, the differences were statistically significant (P0.05). Conclusion: the continuous intervention of clinical pharmacists in the use of antibiotics during the perioperative period of thoracic surgery can obviously improve the rationality of clinical use of antimicrobial agents, reduce the clinical use of antibiotics, reduce the medical expenses of patients, and improve the quality of clinical medical services.
【作者单位】：广州医科大学附属肿瘤医院;广州医科大学附属第一医院;
【基金】：广东省自筹经费类科技计划项目(No.2013-6)
【分类号】：R969.3

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