首次在人中证实内皮素直接介导利钠利尿作用
发布时间：2018-10-04 20:22
【摘要】：正内皮素受体拮抗剂是慢性肾脏病及难治性高血压新的潜在治疗药物,但可导致钠水潴留。动物研究发现,此副作用是由于肾小管内皮素B受体阻滞所致。该研究的目的是通过给予亚升压剂量的内皮素1前体,即大内皮素1,探讨人肾小管内皮素信号在盐转运中的作用。在10个健康志愿者中进行一项二期随机、双盲、安慰剂对照交叉试验。限盐后静脉给予研究对
[Abstract]:Positive endothelin receptor antagonist is a new potential therapy for chronic kidney disease and refractory hypertension, but it can lead to sodium retention. Animal studies have found that this side effect is due to tubular endothelin B receptor block. The aim of this study was to investigate the role of human renal tubular endothelin signal in salt transport by subpressor dose of endothelin 1 precursor, large endothelin 1. A two-phase randomized, double blind, placebo-controlled cross-control trial was conducted in 10 healthy volunteers. Study of intravenous administration after salt limitation
【分类号】：R969
[Abstract]:Positive endothelin receptor antagonist is a new potential therapy for chronic kidney disease and refractory hypertension, but it can lead to sodium retention. Animal studies have found that this side effect is due to tubular endothelin B receptor block. The aim of this study was to investigate the role of human renal tubular endothelin signal in salt transport by subpressor dose of endothelin 1 precursor, large endothelin 1. A two-phase randomized, double blind, placebo-controlled cross-control trial was conducted in 10 healthy volunteers. Study of intravenous administration after salt limitation
【分类号】：R969
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