HPLC法测定利伐沙班有关物质
发布时间：2018-10-04 20:37
【摘要】：目的建立HPLC法测定利伐沙班原料药的有关物质。方法采用Purospher Star RP-18endcapped(55mm×4.0mm,3μm)色谱柱;10mmol·L-1磷酸为流动相A,乙腈为流动相B,梯度洗脱;进样量为5μL;检测波长为250nm;流速为1.0mL·min-1;柱温为45℃。结果利伐沙班及各杂质能得到良好的分离,3批样品中单一杂质的含量质量分数均小于0.1%。结论该方法可用于利伐沙班原料药中有关物质的检测。
[Abstract]:Objective to establish a HPLC method for the determination of related substances in rivastaban. Methods Purospher Star RP-18endcapped column (55mm 脳 4.0 mm ~ (3 渭 m) was used as mobile phase A, acetonitrile as mobile phase B, injection volume 5 渭 L, detection wavelength 250 nm, flow rate 1.0mL min-1; column temperature 45 鈩，
本文编号：2251802
[Abstract]:Objective to establish a HPLC method for the determination of related substances in rivastaban. Methods Purospher Star RP-18endcapped column (55mm 脳 4.0 mm ~ (3 渭 m) was used as mobile phase A, acetonitrile as mobile phase B, injection volume 5 渭 L, detection wavelength 250 nm, flow rate 1.0mL min-1; column temperature 45 鈩，
本文编号：2251802
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