雷帕霉素互变异构体的分离和鉴定
发布时间：2018-10-08 14:06
【摘要】：目的分离、纯化HPLC图谱中一直伴随着雷帕霉素的异构体(Rap-T)和它的转化产物并鉴定它们的化学结构。方法制备液相色谱仪分离Rap-T及其转化产物;HPLC跟踪分析Rap-T在25℃、50%乙腈-水溶液中不同时间的转化结果 ;对Rap-T及其转化产物进行理化性质和波谱分析。结果 Rap-T是雷帕霉素化学结构上的吡喃环扩展为氧杂环庚烷的化合物,其转化产物的化学结构与雷帕霉素一致;Rap-T与雷帕霉素在25℃、50%乙腈-水溶液中能相互转化。结论 Rap-T是雷帕霉素的互变异构体,二者可以相互转化。
[Abstract]:Objective to isolate and purify the isomer (Rap-T) of rapamycin (Rap-T) and its transformation products from HPLC and to identify their chemical structures. Methods Rap-T was separated by liquid chromatography and its transformation product was used to trace and analyze the conversion results of Rap-T in 50% acetonitrile-aqueous solution at 25 鈩，
本文编号：2257040
[Abstract]:Objective to isolate and purify the isomer (Rap-T) of rapamycin (Rap-T) and its transformation products from HPLC and to identify their chemical structures. Methods Rap-T was separated by liquid chromatography and its transformation product was used to trace and analyze the conversion results of Rap-T in 50% acetonitrile-aqueous solution at 25 鈩，
本文编号：2257040
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