聚合物微针介导经皮给药的研究

发布时间：2018-10-11 08:07

【摘要】：皮肤角质层是药物经皮渗透的主要障碍,尤其是对大分子药物或亲水性药物分子,而微米尺寸的微针可以以微创的方式刺穿皮肤角质层,产生可逆的微孔道,促进药物渗透,进而克服传统药物经皮渗透率低的问题。同时,由于微针插入皮肤的深度有限,不触及皮下痛觉神经,可以避免引起疼痛。聚合物微针不仅具有足够的机械强度刺穿皮肤角质层,而且具有优异的生物相容性、载药量可调节范围大等特点,即使断裂在皮肤内,也不会产生安全问题。聚合物微针的众多优势使其在经皮传递药物方面具有广阔的前景,是当前经皮给药领域的研究热点。本文将从聚合物微针的种类、制备方法、经皮给药应用等方面详细综述聚合物微针的最新研究进展,并对这一领域的未来发展进行展望。
[Abstract]:The skin cuticle is a major barrier to drug transdermal penetration, especially for macromolecular drugs or hydrophilic drug molecules, and micron-sized microneedles can penetrate the cuticle of the skin in a minimally invasive manner, producing reversible micropores that promote drug penetration. Thus, the problem of low transdermal permeability of traditional drugs is overcome. At the same time, due to the limited depth of microneedle insertion into the skin, do not touch the subcutaneous pain nerve, can avoid pain. Polymer microneedles not only have enough mechanical strength to penetrate the cuticle of skin, but also have excellent biocompatibility and wide range of drug loading. Even if it breaks in the skin, it will not cause safety problems. Polymer microneedles have a broad prospect in the field of transdermal drug delivery due to their many advantages, which is a hot spot in the field of transdermal drug delivery. In this paper, the latest research progress of polymer microneedles is reviewed in detail from the aspects of kinds, preparation methods, percutaneous drug delivery and so on, and the future development in this field is prospected.
【作者单位】：浙江大学高分子科学与工程学系教育部高分子合成与功能构造重点实验室;
【基金】：浙江省自然科学基金项目(No.LY18E030001) 国家自然科学基金项目(No.21474087) 国家国际科技合作专项(No.2015DFA51010)资助~~
【分类号】：R943;TQ317

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