运用全面触发工具检测老年患者药物不良事件

发布时间：2018-10-17 18:08

【摘要】：目的:探讨全面触发工具(global trigger tool,GTT)用于我国老年患者药物不良事件(adverse drug event,ADE)检测的适用性。方法:随机抽取四川大学华西医院,出院日期在2015年1月1日至2015年12月31日的60岁以上老年患者的病历信息,每月40例共480例。使用GTT推荐的13项触发器并进行筛查后,确定ADE并对其进行严重程度分级。同时,根据病例审查结果对目前的13项触发器进行修正。结果:在审查的480例住院病例中,共发现226例ADE。ADE/1 000患者天为8.31,ADE/100例患者为47.08%,173例患者至少发生过1次ADE的人数占总人数的36.04%。GTT推荐的13项触发器有11项触发器阳性,触发器阳性频次527次,共涉及164例不良事件。另有62例常见ADE无对应触发器支持。根据上述结果,建议可删除2项原有触发器并同时加入5项新的触发器。结论:GTT在检测老年患者药物不良事件方面具有较强的适用性,并为防范用药风险提供参考依据,在我国的医疗机构中有推广价值,但还需要进一步完善。
[Abstract]:Objective: to investigate the applicability of (global trigger tool,GTT (a comprehensive trigger tool) in the detection of adverse drug events (adverse drug event,ADE) in elderly patients in China. Methods: a total of 480 patients aged over 60 years old from January 1, 2015 to December 31, 2015 were randomly selected from Huaxi Hospital of Sichuan University. 13 triggers recommended by GTT were used and screened, then ADE was determined and graded. At the same time, according to the results of the case review, the current 13 triggers were revised. Results: of the 480 inpatients examined, 11 of the 13 triggers recommended by 36.04%.GTT were found to be positive in 226 patients with ADE.ADE/1 ADE days (8.31 / 100) and 47.08% (173 / 173) of the total number of 36.04%.GTT recommended triggers. The frequency of flip-flop was 527, involving 164 cases of adverse events. There were 62 cases of common ADE without corresponding trigger support. Based on the above results, it is suggested that two old flip-flops can be deleted and 5 new flip-flops can be added simultaneously. Conclusion: GTT has strong applicability in the detection of drug adverse events in elderly patients and provides reference basis for prevention of drug risk. It is worth popularizing in medical institutions of our country, but it still needs to be further improved.
【作者单位】：四川大学华西药学院;四川大学华西医院药剂科;
【分类号】：R95

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