利福平脂质体温敏型原位凝胶的制备及其体外释药特征研究

发布时间：2018-10-20 12:22

【摘要】：目的制备利福平脂质体温敏型原位凝胶,并对其体外性质进行研究。方法采用薄膜分散法制备利福平脂质体,并对利福平脂质体进行表征研究;以泊洛沙姆188、泊洛沙姆407为凝胶基质,制备利福平脂质体温敏型原位凝胶;以无膜溶出模型研究温敏型原位凝胶体外累积溶蚀率;采用透析袋法分析药物体外释放情况。结果制备的利福平脂质体平均粒径、聚分散指数、Zeta电位、包封率和载药量分别为(149.0±5.67)nm、0.275±0.056、?(29.8±1.59)m V、(79.6±2.67)%,(18.6±0.25)%;利福平脂质体温敏型原位凝胶的胶凝温度为(34.3±0.6)℃。体外溶蚀曲线和体外释药曲线均符合零级动力学特征。结论利福平脂质体温敏型原位凝胶的制备工艺简单易行,体外释放显示其有很好的缓释作用。
[Abstract]:Objective to prepare rifampicin lipids in situ gel and study its properties in vitro. Methods Rifampicin liposomes were prepared by thin-film dispersion method, and the liposomes were characterized by using Poloxamer 188and Poloxamer 407 as gel matrix, and rifampicin liposome thermo-sensitive in situ gel was prepared with Poloxamer 188and Poloxamer 407 as gel matrix. The in vitro cumulative dissolution rate of thermosensitive in situ gel was studied by using membrane free dissolution model, and the drug release in vitro was analyzed by dialysate bag method. Results the average particle size, polydispersity index, Zeta potential, encapsulation efficiency and drug loading capacity of rifampicin liposome were (149.0 卤5.67) nm,0.275 卤0.056? (29.8 卤1.59) m V, (79.6 卤2.67)%, (18.6 卤0.25)%, respectively, and the gelation temperature of rifampicin liposome in situ gel was (34.3 卤0.6) 鈩，

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