青霉素结合蛋白及其介导细菌耐药的研究进展

发布时间：2018-11-04 14:43

【摘要】：青霉素结合蛋白(PBPs)是一类广泛存在于细菌细胞膜表面的膜蛋白,是β-内酰胺类抗生素的主要作用靶位。在细菌合成细胞壁肽聚糖的过程中,PBPs主要发挥糖基转移酶、肽基转移酶和D-丙氨酰-D-丙氨酸羧肽酶(D,D-羧肽酶)活性,是细菌生长繁殖中不可或缺的酶。不同种类细菌所含PBPs各不相同,其结构的改变、数量的增多、与抗生素亲和力的下降以及产生新的青霉素结合蛋白是直接导致细菌对β-内酰胺类抗生素产生耐药性的重要原因。随着各类抗菌药物在临床上的广泛应用,细菌对抗菌药物的耐药问题日趋严重,其耐药水平也越来越高。因此,近年来全球围绕PBPs开展的研究工作越来越多。本文对PBPs的分类、结构和功能、与细菌耐药性的关系及检测方法的最新研究进展进行综述,并对未来可能的研究方向进行展望。
[Abstract]:Penicillin binding protein (PBPs) is a kind of membrane protein which widely exists on the surface of bacterial cell membrane and is the main target of 尾-lactam antibiotics. In the process of bacterial cell wall peptidoglycan synthesis, PBPs mainly plays an important role in bacterial growth and reproduction because of its activities of glycosyltransferase, peptidyl transferase and D-alanyl-D-alanine carboxypeptidase. Different species of bacteria contain different PBPs, the structure of the changes, the increase in the number, The decrease of affinity to antibiotics and the production of new penicillin binding proteins are the main causes of bacterial resistance to 尾-lactam antibiotics. With the wide application of various kinds of antimicrobial agents in clinic, the problem of bacterial resistance to antimicrobial agents is becoming more and more serious, and the level of drug resistance is becoming higher and higher. Therefore, in recent years, the global research work around PBPs is more and more. In this paper, the classification, structure and function of PBPs, the relationship between PBPs and bacterial resistance and the latest research progress of detection methods are reviewed, and the possible research directions in the future are prospected.
【作者单位】：江苏师范大学生命科学学院;
【基金】：江苏省大学生创新创业训练计划项目(No.201610320087Y)~~
【分类号】：R978.1

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