蒙脱石及其制剂吸附力测定方法研究
发布时间:2018-11-09 11:32
【摘要】:目的:对现行蒙脱石及其制剂质量标准中吸附力检查的原理及方法进行深入研究,拟以非毒性试剂三氯六氨合钴(Ⅲ)替代目前所使用的价格昂贵且剧毒的硫酸士的宁测定蒙脱石吸附力。方法:经对蒙脱石吸附力测定原理的理论论证,优化了吸附力测定方法,利用正交设计软件确定反应条件为37℃水浴放置1 h,以紫外-可见分光光度法在474 nm测定,对方法的线性、精密度和溶液稳定性进行了方法学验证。结果:经对21家企业的39批原料与制剂样品测定,原料结果在1.024~1.174 mmol·g~(-1)之间,散剂结果在1.018~1.238 mmol·g~(-1)之间,分散片结果在0.894~1.130 mmol·g~(-1)之间,所有样品结果与采用硫酸士的宁测定吸附力的结果间换算平均系数为0.43,与理论推导一致,方法可行。结论:三氯六氨合钴(Ⅲ)可替代硫酸士的宁作为蒙脱石吸附力测定的标志物,试验安全,无污染,经济,简便。
[Abstract]:Objective: to study the principle and method of adsorption test in the quality standard of montmorillonite and its preparation. It is proposed that the adsorption capacity of montmorillonite should be determined by replacing the expensive and highly toxic strychnine sulfate currently used with the nontoxic reagent cobalt trichlorohexaaminoate (鈪,
本文编号:2320286
[Abstract]:Objective: to study the principle and method of adsorption test in the quality standard of montmorillonite and its preparation. It is proposed that the adsorption capacity of montmorillonite should be determined by replacing the expensive and highly toxic strychnine sulfate currently used with the nontoxic reagent cobalt trichlorohexaaminoate (鈪,
本文编号:2320286
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