3种华法林剂量预测模型与汉族人群的维持剂量相关性评价

发布时间：2018-11-14 12:20

【摘要】：目的:评价3种不同华法林剂量预测模型对汉族人群华法林每日维持剂量预测的准确性。方法:选取86例行VKORC1、CYP2C9基因多态性检测,华法林抗凝治疗且INR达标患者,收集患者平均每日华法林维持剂量、人口学信息及临床情况等;通过比较患者的实际剂量与预测剂量的差异,评价Gage模型、国际华法林药物基因组协会(IWPC)和药物作用靶点基因检测技术指南(指南)等推荐的华法林剂量预测模型的准确性。结果:Gage模型的预测剂量稍小于患者实际剂量,但没有统计学差异[(3.81±0.95)mg vs.(4.19±1.19)mg,P=0.199],预测准确率61.6%,而IWPC、指南模型的平均预测剂量均低于患者实际剂量[(3.48±0.85)mg,P=0.025和(3.38±0.66)mg,P=0.007)];预测准确率分别为48.8%和41.8%。结论:GAGE模型更适合威海地区汉族人群,但需大样本研究进一步验证其准确性。
[Abstract]:Objective: to evaluate the accuracy of three different warfarin dose prediction models for daily maintenance dose prediction of warfarin in Han population. Methods: 86 patients with VKORC1,CYP2C9 gene polymorphism, warfarin anticoagulant therapy and INR standard were selected. The average daily maintenance dose of warfarin, demographic information and clinical information were collected. The Gage model was evaluated by comparing the difference between the actual dose and the predicted dose. The accuracy of warfarin dose prediction models recommended by the International Warfarin Pharmaceutical Genome Association (IWPC) and the Technical guidelines for Detection of Drug Action Target genes (guidelines). Results: the predicted dose of Gage model was slightly smaller than the actual dose of patients, but there was no statistical difference [(3.81 卤0.95) mg vs. (4.19 卤1.19) mg,P=0.199]. The accuracy of prediction was 61.6%, while that of IWPC, was 61.6%. The average predicted dose of the guided model was lower than the actual dose [(3.48 卤0.85) mg,P=0.025 and (3.38 卤0.66) mg,P=0.007]. The prediction accuracy was 48.8% and 41.8%, respectively. Conclusion: GAGE model is more suitable for the Han population in Weihai area, but it needs to be further verified by a large sample study.
【作者单位】：威海市立医院药剂科;
【基金】：威海市科技发展计划项目(编号:2010-3-86-4)
【分类号】：R969

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