丁螺环酮和米安色林对梁氏情境应激箱诱导小鼠焦虑和抑郁样行为的影响
发布时间：2018-11-14 12:35
【摘要】：目的设计和建立梁氏情境应激箱,通过观察抗焦虑和抗抑郁药对小鼠行为学指标的影响,评价梁氏情境应激箱对小鼠焦虑和(或)抑郁样情绪反应的诱导作用。方法梁氏情境应激箱由中央区和3个外周臂构成。ICR小鼠分别ip给予抗焦虑药物丁螺环酮(0.5和1.0 mg·kg~(-1))和抗抑郁药物米安色林(0.25和0.5 mg·kg~(-1)),观察小鼠首次进入中央区的潜伏期、中央区停留时间、中央区活动路程、外周区活动路程、区域间穿梭次数和总活动度。结果 1丁螺环酮0.5和1.0 mg·kg~(-1)明显缩短小鼠首次进入中央区的潜伏期,分别缩短了71.9%(P0.05)和77.9%(P0.05);剂量依赖性地增加中央区停留时间,各增加了59.5%和73.8%(P0.05);丁螺环酮0.5和1.0 mg·kg~(-1)均可显著减少小鼠区域间穿梭次数(P0.05),但对其中央区活动路程、外周区活动路程和总活动度无明显影响;2米安色林0.25和0.5 mg·kg~(-1)明显缩短小鼠首次进入中央区的潜伏期,分别缩短了72.4%(P0.05)和82.3%(P0.05);剂量依赖性地增加中央区停留时间,各增加了39.1%和43.9%(P0.05);米安色林剂量依赖性地增加中央区活动路程(P0.05)及区域间穿梭次数(P0.05),但对外周区活动路程和总活动度无明显影响。结论梁氏情境应激箱对小鼠焦虑和(或)抑郁样情绪反应具有明确的诱导作用,可作为一个新的焦虑抑郁共病动物模型研究其病理生理机制,筛选和评价新型抗焦虑和(或)抗抑郁药物。
[Abstract]:Objective to design and establish the Liang's situational stress box, and to evaluate the inducing effect of Liang's situational stress box on anxiety and / or depression-like emotional response in mice by observing the effect of antianxiety and antidepressant drugs on the behavioral indexes of mice. Methods the stress box consisted of three peripheral arms and the central area. ICR mice were given the antianxiety drug buspirone (0.5 and 1.0 mg kg~ (-1) and the antidepressant mianserin (0.25 and 1.0 mg kg~ (-1), respectively). 0.5 mg kg~ (-1),) The incubation period of entering the central area for the first time, the residence time of the central area, the distance of the activity in the peripheral area, the times of interregional shuttle and the total activity were observed. Results 1 buspirone 0.5 and 1.0 mg kg~ (-1) significantly shortened the latency of entering the central area for the first time by 71.9% (P0.05) and 77.9% (P0.05), respectively. The residence time of central area was increased by 59.5% and 73.8% in a dose-dependent manner (P0.05). Buspirone 0.5 and 1.0 mg kg~ (-1) significantly decreased the number of interregional shuttles in mice (P0.05), but had no significant effect on the distance of activity in the central region, the distance of activity in the peripheral region and the total activity. (2) 0.25 and 0.5 mg kg~ (-1) of mianserine significantly shortened the latency of entering the central area of mice for the first time by 72.4% (P0.05) and 82.3% (P0.05), respectively. The residence time of central area was increased by 39.1% and 43.9% in a dose-dependent manner (P0.05). Mianserin dose-dependently increased the activity distance of central area (P0.05) and the number of interregional shuttle (P0.05), but the distance of activity and the total activity of peripheral area had no significant effect. Conclusion Liang's situational stress box can induce anxiety and / or depression-like emotional response in mice. It can be used as a new animal model to study the pathophysiological mechanism of anxiety and depression syndromes. Screening and evaluation of new anti-anxiety and / or anti-depressants.
【作者单位】： 北京大学基础医学院药理学系;北京大学药学院分子与细胞药理学系;
【基金】：十二五科技支撑计划项目(2011BAK04B08)~~
【分类号】：R965
本文编号：2331177
[Abstract]:Objective to design and establish the Liang's situational stress box, and to evaluate the inducing effect of Liang's situational stress box on anxiety and / or depression-like emotional response in mice by observing the effect of antianxiety and antidepressant drugs on the behavioral indexes of mice. Methods the stress box consisted of three peripheral arms and the central area. ICR mice were given the antianxiety drug buspirone (0.5 and 1.0 mg kg~ (-1) and the antidepressant mianserin (0.25 and 1.0 mg kg~ (-1), respectively). 0.5 mg kg~ (-1),) The incubation period of entering the central area for the first time, the residence time of the central area, the distance of the activity in the peripheral area, the times of interregional shuttle and the total activity were observed. Results 1 buspirone 0.5 and 1.0 mg kg~ (-1) significantly shortened the latency of entering the central area for the first time by 71.9% (P0.05) and 77.9% (P0.05), respectively. The residence time of central area was increased by 59.5% and 73.8% in a dose-dependent manner (P0.05). Buspirone 0.5 and 1.0 mg kg~ (-1) significantly decreased the number of interregional shuttles in mice (P0.05), but had no significant effect on the distance of activity in the central region, the distance of activity in the peripheral region and the total activity. (2) 0.25 and 0.5 mg kg~ (-1) of mianserine significantly shortened the latency of entering the central area of mice for the first time by 72.4% (P0.05) and 82.3% (P0.05), respectively. The residence time of central area was increased by 39.1% and 43.9% in a dose-dependent manner (P0.05). Mianserin dose-dependently increased the activity distance of central area (P0.05) and the number of interregional shuttle (P0.05), but the distance of activity and the total activity of peripheral area had no significant effect. Conclusion Liang's situational stress box can induce anxiety and / or depression-like emotional response in mice. It can be used as a new animal model to study the pathophysiological mechanism of anxiety and depression syndromes. Screening and evaluation of new anti-anxiety and / or anti-depressants.
【作者单位】： 北京大学基础医学院药理学系;北京大学药学院分子与细胞药理学系;
【基金】：十二五科技支撑计划项目(2011BAK04B08)~~
【分类号】：R965
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