儿童抗癫痫药物超说明书用药调查分析

发布时间：2018-11-18 21:03

【摘要】：目的:了解抗癫痫药物在儿童患者中超说明书用药的情况,并分析原因,为儿童抗癫痫药物的合理使用提供参考。方法:分层随机抽取2012年9月—2013年8月的抗癫痫药物门诊处方,参照药品说明书的内容,判断使用抗癫痫药物的处方是否存在超说明书用药,统计分析超说明书用药的类型,计算超说明书用药发生率。结果:2 400张处方中,超说明书用药共955张,占所有处方的39.79%,主要是超适应证和超年龄用药。抗癫痫药物超说明书用药比例由高到低分别是:唑尼沙胺片(100%)、左乙拉西坦片(95.19%)、拉莫三嗪片(48.08%)、丙戊酸钠片(43.33%)等。结论:抗癫痫药在儿童癫痫患者中超说明书用药的发生率较高,尤其是唑尼沙胺和左乙拉西坦。其中大部分超适应证用药是有循证医学依据的,并非医师盲目用药。儿童用药的特殊性也是造成超说明书用药的重要原因。应尽可能规范超说明书用药行为,促进临床合理用药。
[Abstract]:Objective: to investigate the use of anti-epileptic drugs in children and analyze the reasons for the use of anti-epileptic drugs in order to provide reference for the rational use of anti-epileptic drugs in children. Methods: the prescriptions of antiepileptic drugs were randomly selected from September 2012 to August 2013. According to the contents of the drug instructions, the superprescriptions of antiepileptic drugs were determined and the types of drugs used in the prescriptions were statistically analyzed. The incidence of drug use was calculated. Results: of the 2 400 prescriptions, 955 were superprescriptions, which accounted for 39.79% of all prescriptions. The proportion of antiepileptic drugs was from high to low: zonisamide tablets (100%), levoethylacetam tablets (95.19%), lamotriazine tablets (48.08%), sodium valproate tablets (43.33%) and so on. Conclusion: the incidence of antiepileptic drugs in children with epilepsy is high, especially zonisamide and levoethoxetam. Most of them are based on evidence-based medicine and are not blindly used by physicians. The particularity of children's drug use is also an important reason for the overstatement of drug use. As far as possible, the behavior of drug use should be standardized to promote the rational use of drugs in clinical practice.
【作者单位】：福建医科大学附属协和医院药学部;
【分类号】：R95

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