利用循证医学方法对前列地尔注射液超说明书用药的评估探讨

发布时间：2018-11-24 09:50

【摘要】：目的:通过对前列地尔注射液专科超说明书用药进行循证评估,为临床处方点评及医嘱审核中超说明书用药的合理性判断提供技术参考。方法:收集某院2015年内分泌科医嘱审核中发现的前列地尔注射液超说明书用药情况,按照Cochrane手册5.1及GRADE系统要求建立超说明书用药的循证评价流程,判断其超说明书用药有无循证依据。结果:医嘱审核汇总后有4项前列地尔注射液超说明书用药现象,其中应用于糖尿病周围神经病变和糖尿病足有指南和(或)权威医学专著记录,评估为有循证证据;应用于糖尿病肾病根据CDSR和DARE结论评估为无循证证据;应用于糖尿病视网膜病变根据对临床试验进行GRADE评级后评估为无循证证据。结论:利用循证评价方法和流程对超说明书用药进行评估,不仅有助于临床药师开展日常工作,更为促进临床合理用药提供了技术支持。
[Abstract]:Objective: to provide a technical reference for the rational judgment of clinical prescriptions and prescriptions in the evaluation of prostadil injection. Methods: according to the requirements of Cochrane Manual 5.1 and GRADE system, the evidence-based evaluation procedure of prostadil injection was established according to the requirement of Cochrane manual 5.1 and GRADE system. To judge whether there is evidence-based basis for the use of drugs in excess of the instructions. Results: after the review of the doctor's orders, there were 4 cases of prostadil injection superprescriptions, among which there were guidelines and / or authoritative medical monographs for diabetic peripheral neuropathy and diabetic foot, which were evaluated as evidence-based evidence. Applied to diabetic nephropathy assessed as unevidence-based according to CDSR and DARE conclusions and applied to diabetic retinopathy based on GRADE rating of clinical trials as unevidence-based evidence. Conclusion: the evaluation method and procedure of evidence-based evaluation not only help the clinical pharmacists to carry out daily work, but also provide technical support for the rational use of drugs in clinical practice.
【作者单位】：皖南医学院第一附属医院;
【分类号】：R97

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