阴离子交换色谱法测定盐酸精氨酸注射液中氯的含量
发布时间：2018-11-24 19:02
【摘要】：目的:建立阴离子交换色谱法测定盐酸精氨酸注射液中氯的含量。方法:色谱柱为阴离子交换柱HAMILTON PRPX100(4.1 mm×250 mm,10μm),以0.1 mol·L-1硝酸钾溶液1 000 m L,加甲醇500 m L和0.1 m L氢氧化四丁基铵溶液(10%),然后加水至5 000 m L为流动相,流速1.0 m L·min-1,检测波长240nm,柱温35℃,进样量100μL。结果:Cl-1质量浓度在0.034~0.272 mg·m L-1范围内,线性关系良好(r=0.999 9),平均回收率(n=9)为99.1%,精密度、重复性、稳定性均符合要求。81批样品氯的测定结果为16.2%~17.6%。结论:本法经方法学验证,可作为盐酸精氨酸注射液中氯含量质量标准控制的方法。
[Abstract]:Objective: to establish anion exchange chromatography for the determination of chlorine in arginine hydrochloride injection. Methods: the chromatographic column consisted of anion exchange column HAMILTON PRPX100 (4.1 mm 脳 250 mm,10 渭 m),) with 0.1 mol L-1 potassium nitrate solution 1 000 mL, methanol 500 mL and 0.1 mL ammonium tetraDing Ji hydroxide solution (10%). The flow rate was 1.0 mL min-1, detection wavelength was 240 nm, column temperature was 35 鈩，
本文编号：2354692
[Abstract]:Objective: to establish anion exchange chromatography for the determination of chlorine in arginine hydrochloride injection. Methods: the chromatographic column consisted of anion exchange column HAMILTON PRPX100 (4.1 mm 脳 250 mm,10 渭 m),) with 0.1 mol L-1 potassium nitrate solution 1 000 mL, methanol 500 mL and 0.1 mL ammonium tetraDing Ji hydroxide solution (10%). The flow rate was 1.0 mL min-1, detection wavelength was 240 nm, column temperature was 35 鈩，
本文编号：2354692
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