一种新型PDE-5抑制剂衍生物的发现及结构鉴定
发布时间：2018-11-24 20:17
【摘要】：基于超高效液相色谱电喷雾四极杆飞行时间串联质谱联用(UPLC-DAD-QTOF-MS)技术检出某保健酒中非法添加了一种磷酸二酯酶-5(PDE-5)抑制剂衍生物,经制备液相色谱分离纯化,采用UPLC-DADQTOF-MS、核磁共振(NMR)和红外光谱(IR)技术对其进行了分析和结构鉴定,确定其为一种新型艾地那非衍生物,国内外均未见报道。
[Abstract]:A phosphodiesterase-5 (PDE-5) inhibitor derivative was detected by ultra-high performance liquid chromatography (HPLC) electrospray quadrupole time-of-flight mass spectrometry (UPLC-DAD-QTOF-MS) technique. UPLC-DADQTOF-MS, NMR (NMR) and IR (IR) techniques were used to analyze and identify its structure. It was identified as a new kind of Edenafil derivative, which has not been reported at home and abroad.
【作者单位】： 河北省药品检验研究院;
【基金】：河北省食品药品监督管理局重点科技项目(ZD2014006)
【分类号】：O657.63;R927
本文编号：2354907
[Abstract]:A phosphodiesterase-5 (PDE-5) inhibitor derivative was detected by ultra-high performance liquid chromatography (HPLC) electrospray quadrupole time-of-flight mass spectrometry (UPLC-DAD-QTOF-MS) technique. UPLC-DADQTOF-MS, NMR (NMR) and IR (IR) techniques were used to analyze and identify its structure. It was identified as a new kind of Edenafil derivative, which has not been reported at home and abroad.
【作者单位】： 河北省药品检验研究院;
【基金】：河北省食品药品监督管理局重点科技项目(ZD2014006)
【分类号】：O657.63;R927
【相似文献】
相关期刊论文 前1条
1 王占良;张建丽;张亦农;;气相色谱-质谱联用法检测保健品中4种PDE-5抑制剂药物[J];质谱学报;2009年05期
相关硕士学位论文 前1条
1 刘金荣;PDE-5抑制剂对野百合碱诱导的大鼠肺动脉高压作用研究[D];中国医科大学;2010年
，本文编号：2354907
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2354907.html
最近更新
教材专著
