不同种类消毒产品的一般毒性评价结果分析

发布时间：2018-12-09 21:42

【摘要】：目的分析不同种类的消毒产品一般毒理学安全性评价结果,为消毒产品的安全性评价的剂量设计和毒性分级提供参考。方法采用统计分析方法,对本研究室急性毒性和亚急性毒性试验的41个化学消毒剂产品试验结果进行分析和评价。结果急性经口毒性试验评价的41个消毒产品中,属实际无毒级的消毒产品占总数的73.2%,属低毒级的消毒产品占总数的26.8%。亚急性毒性试验评价的41个消毒产品中,无可见有害作用水平(NOAEL)为1 000 mg/kg的消毒产品占总数的66.7%,NOAEL为500~1 000 mg/kg的消毒产品占总数的13.3%,NOAEL为100~500 mg/kg的消毒产品占总数的6.7%,NOAEL为10~100 mg/kg的消毒产品占总数的13.3%。结论醇类、碘类、胍类消毒产品属实际无毒级,较为安全;过氧化物类、含氯类、醛类消毒产品毒性相对较大。
[Abstract]:Objective to analyze the results of general toxicological safety assessment of different disinfection products and to provide reference for dose design and toxicity classification of disinfection products. Methods the results of 41 chemical disinfectant products of acute and subacute toxicity tests in our laboratory were analyzed and evaluated by statistical analysis. Results among the 41 disinfectant products evaluated by acute oral toxicity test, 73.2% of the total disinfection products were of non-toxic grade, and 26.8of the total disinfection products were of low toxicity grade. Of the 41 disinfection products evaluated by the subacute toxicity test, the disinfection products with no visible harmful effect level (NOAEL) 1 000 mg/kg) accounted for 66.7% of the total disinfection products, and the disinfection products with the NOAEL of 500 mg/kg accounted for 13.3% of the total. The disinfection products whose NOAEL was 100g / 500 mg/kg accounted for 6.7% of the total. The disinfection products with NOAEL of 10 ~ 100 mg/kg accounted for 13.3% of the total. Conclusion the disinfection products of alcohol, iodine and guanidine are non-toxic and safe, and peroxides, chlorides and aldehydes are relatively toxic.
【作者单位】：军事医学科学院疾病预防控制所;
【基金】：国家重点基础研究发展计划(973计划)项目(2011CB503803)
【分类号】：R965

【参考文献】