利奈唑胺治疗急性感染时导致血浆谷浓度过低的危险因素
发布时间：2018-12-11 02:52
【摘要】：正利奈唑胺是时间依赖性抗生素,与临床疗效相关的药动学参数包括血药浓度高于最低抑菌浓度(MIC)的时间百分比(%TMIC)和用药达稳态时24 h血药时曲线下面积与MIC的比值(AUC24/MIC)。一项回顾性研究结果显示,如果利奈唑胺血药浓度在整个给药间期均维持在MIC之上,或者AUC24/MIC为80至120,临床治疗成功率更高。但最近一些研究结果显示,部分患者利奈唑胺谷浓度低于利奈唑
[Abstract]:Rnazolidomide is a time dependent antibiotic. The pharmacokinetic parameters related to the clinical efficacy included the percentage of time (% TMIC) in which the serum drug concentration was higher than the minimum inhibitory concentration (MIC) and the ratio of area to MIC (AUC24/MIC) under the blood drug time curve at 24 h when the drug reached steady state. A retrospective study showed that the clinical success rate was higher if the plasma concentration of linazolamide remained above MIC throughout the administration period or if AUC24/MIC was between 80 and 120. However, some recent studies have shown that some patients have lower concentrations of linazolamide than those of Linenazole.
【分类号】：R969
[Abstract]:Rnazolidomide is a time dependent antibiotic. The pharmacokinetic parameters related to the clinical efficacy included the percentage of time (% TMIC) in which the serum drug concentration was higher than the minimum inhibitory concentration (MIC) and the ratio of area to MIC (AUC24/MIC) under the blood drug time curve at 24 h when the drug reached steady state. A retrospective study showed that the clinical success rate was higher if the plasma concentration of linazolamide remained above MIC throughout the administration period or if AUC24/MIC was between 80 and 120. However, some recent studies have shown that some patients have lower concentrations of linazolamide than those of Linenazole.
【分类号】：R969
【相似文献】
相关期刊论文 前10条
1 袁进;;利奈唑胺致血小板减少1例[J];医药导报;2010年09期
2 金东;胡马洪;陈扬波;季春莲;张庚;;利奈唑胺治疗呼吸机相关性肺炎的疗效分析[J];中华医院感染学杂志;2011年21期
3 穆玉;范春芳;朱铁梁;吴志恒;;重症患者利奈唑胺所致血小板减少危险因素分析[J];中国感染与化疗杂志;2012年01期
4 袁小玲;缪炯q，
本文编号：2371727
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2371727.html
最近更新
教材专著
