三氧化二砷注射液毒性防治策略研究进展
发布时间：2018-12-17 10:23
【摘要】：砷是众所周知的一类致癌源,能诱发多种癌症,但其衍生物三氧化二砷(arsenic trioxide,As2O3)却是一种很有潜力的抗癌物,对于急性早幼粒白血病(acute promyelocytic leukemia,APL)等多种肿瘤均具有良好的治疗效果。但As2O3毒性反应较强,这使其临床应用受到限制。因此,预防As2O3在治疗过程中产生的毒副作用越来越得到重视。目前有研究显示可通过改良给药方式、与其他药物联合应用、更新药物剂型等方式来降低其不良反应发生。笔者结合国内外相关文献就防治As2O3毒副作用的实验和临床进展作一综述。
[Abstract]:Arsenic is a well-known carcinogen that can induce many kinds of cancers, but its derivative arsenic trioxide (arsenic trioxide,As2O3) is a potential anticancer agent for acute promyelocytic leukemia (acute promyelocytic leukemia,). APL) and other tumors have good therapeutic effect. However, the toxicity of As2O3 is strong, which limits its clinical application. Therefore, more and more attention has been paid to the prevention of toxic side effects of As2O3 in the course of treatment. Recent studies have shown that adverse reactions can be reduced by improved administration, combined use with other drugs, and renewal of drug formulations. The experimental and clinical progress in the prevention and treatment of toxic and side effects of As2O3 was reviewed in combination with the relevant literature at home and abroad.
【作者单位】： 哈尔滨医科大学药理教研室黑龙江省生物医药重点实验室-省部共建国家重点实验室培育基地;
【基金】：黑龙江省教育厅科学技术研究资助项目(12511317)
【分类号】：R96
本文编号：2384075
[Abstract]:Arsenic is a well-known carcinogen that can induce many kinds of cancers, but its derivative arsenic trioxide (arsenic trioxide,As2O3) is a potential anticancer agent for acute promyelocytic leukemia (acute promyelocytic leukemia,). APL) and other tumors have good therapeutic effect. However, the toxicity of As2O3 is strong, which limits its clinical application. Therefore, more and more attention has been paid to the prevention of toxic side effects of As2O3 in the course of treatment. Recent studies have shown that adverse reactions can be reduced by improved administration, combined use with other drugs, and renewal of drug formulations. The experimental and clinical progress in the prevention and treatment of toxic and side effects of As2O3 was reviewed in combination with the relevant literature at home and abroad.
【作者单位】： 哈尔滨医科大学药理教研室黑龙江省生物医药重点实验室-省部共建国家重点实验室培育基地;
【基金】：黑龙江省教育厅科学技术研究资助项目(12511317)
【分类号】：R96
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【共引文献】
相关期刊论文 前2条
1 韩继广;薛英威;张纯慧;李宝馨;杨宝锋;;三氧化二砷对胃癌耐药细胞P-gp、GST-s表达的抑制[J];哈尔滨医科大学学报;2009年01期
2 王勋;殷昊;周晋;张黎明;;侧脑室注射中药提取物三氧化二砷对海马神经元Kv4.2和Kv4.3钾通道表达的影响[J];中医药学报;2013年05期
，本文编号：2384075
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