蛋白多肽类药物口服纳米给药:现状、问题与前景
发布时间：2019-01-05 19:29
【摘要】：背景:研发药物新剂型和制剂新技术已成为有望提高蛋白多肽利用率的热点,尤其是近几年的纳米技术的研究进展更是促进了蛋白质药物的临床应用。目的:综述蛋白口服纳米给药的研究现状。方法:应用计算机检索CNKI数据库、SCI数据库1996至2014年文献,检索中英文关键词为"蛋白多肽,纳米粒,口服制剂;protein,peptide drugs,nanoparticles,oral administration"。结果与结论:纳米材料种类、纳米粒粒径、表面电荷及其表面修饰等对药物的包封率、释药速度、纳米粒在胃肠道内的稳定性及透过肠黏膜的能力等方面有很大影响。纳米粒可增加蛋白药物的稳定性,提高药物的生物利用度;纳米粒的靶向性可减少某些药物的不良反应;纳米粒的缓释作用可以减少药物的用量,增加药物的体内循环时间。但纳米技术目前仍有很多问题有待解决:制备过程中不可避免地会使一些蛋白药物丧失活性;药物的包封率及载药量有待提高;蛋白突释问题不能完全解决;纳米粒目前大规模生产还很困难等。
[Abstract]:Background: the research and development of new drug formulations and new preparation technology has become a hot point in improving the utilization rate of protein peptides, especially in recent years, the research progress of nanotechnology has promoted the clinical application of protein drugs. Objective: to review the research status of oral nano-administration of protein. Methods: CNKI database and SCI database from 1996 to 2014 were searched by computer. The key words in Chinese and English were "protein polypeptide, nanoparticles, oral preparation; protein,peptide drugs,nanoparticles,oral administration". Results & conclusion: the kinds of nanomaterials, particle size, surface charge and surface modification have great influence on encapsulation efficiency, drug release rate, stability of gastrointestinal tract and ability of permeating intestinal mucosa. Nanoparticles can increase the stability of protein drugs and increase the bioavailability of drugs; the targeting of nanoparticles can reduce the adverse reactions of some drugs; the sustained release of nanoparticles can reduce the dosage of drugs and increase the time of drug circulation in vivo. However, there are still many problems to be solved in nanotechnology: some protein drugs will be inactivated inevitably in the preparation process, the encapsulation efficiency and drug loading should be improved, the problem of sudden release of protein can not be completely solved. At present, it is very difficult to produce nanocrystalline particles in large scale.
【作者单位】： 烟台大学药学院;
【分类号】：R944
[Abstract]:Background: the research and development of new drug formulations and new preparation technology has become a hot point in improving the utilization rate of protein peptides, especially in recent years, the research progress of nanotechnology has promoted the clinical application of protein drugs. Objective: to review the research status of oral nano-administration of protein. Methods: CNKI database and SCI database from 1996 to 2014 were searched by computer. The key words in Chinese and English were "protein polypeptide, nanoparticles, oral preparation; protein,peptide drugs,nanoparticles,oral administration". Results & conclusion: the kinds of nanomaterials, particle size, surface charge and surface modification have great influence on encapsulation efficiency, drug release rate, stability of gastrointestinal tract and ability of permeating intestinal mucosa. Nanoparticles can increase the stability of protein drugs and increase the bioavailability of drugs; the targeting of nanoparticles can reduce the adverse reactions of some drugs; the sustained release of nanoparticles can reduce the dosage of drugs and increase the time of drug circulation in vivo. However, there are still many problems to be solved in nanotechnology: some protein drugs will be inactivated inevitably in the preparation process, the encapsulation efficiency and drug loading should be improved, the problem of sudden release of protein can not be completely solved. At present, it is very difficult to produce nanocrystalline particles in large scale.
【作者单位】： 烟台大学药学院;
【分类号】：R944
【参考文献】
相关期刊论文 前4条
1 王宝江;杨爽;李丹;;蛋白口服给药的研究进展[J];中国医药导刊;2008年08期
2 黄健;高春生;梅兴国;;多肽和蛋白类药物口服给药的可行性探讨[J];国际药学研究杂志;2007年04期
3 谢向阳;林雯;李e，
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