微量元素硒的体内过程及生物学效应研究进展

发布时间：2019-01-23 12:43

【摘要】：硒(Se,相对分子质量78.96),是一种人体必需的非金属微量元素。近年来,越来越多的研究发现,体内硒的水平低可能是影响人类某些重大疾病发生的原因之一,使对硒的研究逐步成为关注的热点。本文阐明了元素硒在体内的生物转化途径以及吸收、分布、代谢、排泄的过程,综述了硒在体内的活性形式硒蛋白(主要Sel P)与多种疾病(如心血管疾病、阿尔兹海默症/帕金森氏症神经退行性疾病、癌症等)发生的相关机制和生物学效应的最新进展,解释并分析了微量元素硒在体内的代谢过程对药理学的意义;同时,也提示硒蛋白及相关作用机制将可能成为药物研究与发现的新靶点而需引起广泛关注。
[Abstract]:Selenium (Se, molecular weight 78. 96) is a necessary non-metallic trace element. In recent years, more and more studies have found that the low level of selenium in the body may be one of the reasons that affect the occurrence of some major diseases of human beings, which makes the study of selenium gradually become the focus of attention. In this paper, the biotransformation pathway and absorption, distribution, metabolism and excretion of elemental selenium in vivo are described. The active forms of selenium protein in vivo (mainly Sel P) and many diseases such as cardiovascular disease) are reviewed. Recent advances in the mechanisms and biological effects of neurodegenerative diseases and cancer in Alzheimer's disease / Parkinson's disease explain and analyze the pharmacological significance of trace element selenium metabolism in vivo. At the same time, it is suggested that selenoprotein and its related mechanism may be a new target for drug research and discovery.
【作者单位】：中国医学科学院北京协和医学院药物研究所;中南民族大学;
【基金】：国家自然科学基金资助项目(81573493,81402997) 创新药物非临床药物代谢及药代/药效研究北京市重点实验室项目(2014AA020803) 中国医学科学院医学与健康科技创新工程项目资助(2016-I2M-3-011)
【分类号】：R96

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