以ANO1蛋白为靶点的钙激活氯通道调节剂研究进展
发布时间：2019-01-28 19:28
【摘要】：钙激活氯通道是广泛存在于人体内的一种阴离子通道,参与分泌、心肌细胞去极化、神经信号传导等多种生理活动。ANO1蛋白是钙激活氯通道的分子基础之一,对ANO1蛋白进行调节能够产生多种药效作用,例如镇痛、治疗痢疾、哮喘、抑制肿瘤等。近10年来发展出许多ANO1蛋白调节剂筛选测试方法,虽然筛选出一系列以ANO1蛋白为靶点的钙激活氯通道调节分子,但是这些分子的药理学作用却并不一致。本文从筛选方法、构效关系、潜在应用前景等多方面对ANO1蛋白调节分子的研究进展进行论述。
[Abstract]:Calcium-activated chloride channel is a kind of anionic channel which is widely present in human body. It is involved in many physiological activities such as secretion, depolarization of cardiac myocytes, nerve signal transduction and so on. ANO1 protein is one of the molecular bases of calcium-activated chloride channel. Regulation of ANO1 protein can produce a variety of pharmacological effects, such as analgesia, dysentery, asthma, tumor suppression and so on. In recent 10 years, many screening and testing methods for ANO1 protein modulators have been developed. Although a series of calcium-activated chloride channel regulators targeting ANO1 proteins have been screened, the pharmacological effects of these molecules are not consistent. In this paper, the research progress of regulatory molecules of ANO1 proteins is reviewed in terms of screening methods, structure-activity relationships and potential application prospects.
【作者单位】： 北京大学药学院天然药物及仿生药物国家重点实验室;江苏恩华药物研究院;
【基金】：北京市自然科学基金资助项目(7172118)
【分类号】：R91
，
本文编号：2417240
[Abstract]:Calcium-activated chloride channel is a kind of anionic channel which is widely present in human body. It is involved in many physiological activities such as secretion, depolarization of cardiac myocytes, nerve signal transduction and so on. ANO1 protein is one of the molecular bases of calcium-activated chloride channel. Regulation of ANO1 protein can produce a variety of pharmacological effects, such as analgesia, dysentery, asthma, tumor suppression and so on. In recent 10 years, many screening and testing methods for ANO1 protein modulators have been developed. Although a series of calcium-activated chloride channel regulators targeting ANO1 proteins have been screened, the pharmacological effects of these molecules are not consistent. In this paper, the research progress of regulatory molecules of ANO1 proteins is reviewed in terms of screening methods, structure-activity relationships and potential application prospects.
【作者单位】： 北京大学药学院天然药物及仿生药物国家重点实验室;江苏恩华药物研究院;
【基金】：北京市自然科学基金资助项目(7172118)
【分类号】：R91
，
本文编号：2417240
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