我院蔗糖铁注射液药物利用评价标准的建立及应用

发布时间：2019-03-02 09:00

【摘要】：目的:为临床合理应用蔗糖铁注射液提供参考。方法:参考相关文献和指南,通过药学和临床专家讨论与修订,从用药指征、用药过程、用药结果3个方面建立蔗糖铁注射液的药物利用评价(DUE)标准,制订并实施干预措施。随机抽取2016年2月蔗糖铁注射液使用总金额排名前5位科室中的56例患者为干预前组,再分别随机抽取相应科室2016年4、6月出院患者作为第1阶段干预组(40例)和第2阶段干预组(53例),比较3组患者干预前后蔗糖铁注射液使用符合标准率及合理性。结果:经过2个阶段干预后,第1阶段干预组和第2阶段干预组患者"用药前监测血清铁蛋白等相关缺铁性指标""溶剂剂量选择""给药频率符合标准""贫血症状好转或贫血相关指标改善"的符合率均显著高于干预前组,差异有统计学意义(P0.05);第2阶段干预组患者"相互作用符合标准"的符合率显著高于第1阶段干预组,差异有统计学意义(P0.05)。第2阶段干预组患者综合合理率为77.34%,显著高于干预前组的41.07%和第1阶段干预组的47.50%,差异有统计学意义(P0.05)。结论:我院建立的蔗糖铁注射液DUE标准有较强的可操作性和实用性,临床药师的有效干预解决了临床用药过程中存在的问题,促进了临床用药的合理性,减少了药品不良反应的发生。
[Abstract]:Objective: to provide reference for the rational application of Sucrose Iron injection. Methods: referring to relevant literatures and guidelines, through discussion and revision by pharmaceutical and clinical experts, (DUE) criteria for drug utilization evaluation of Sucrose Iron injection were established from three aspects: indication, process and results of drug use. Develop and implement interventions. In February 2016, 56 patients in the top 5 departments were randomly selected as the pre-intervention group. Then randomly selected the patients discharged from the corresponding departments in April and June 2016 as the first stage intervention group (40 cases) and the second stage intervention group (53 cases), and compared the standard rate and rationality of the use of Sucrose Iron injection before and after intervention in the three groups. Results: after two stages of intervention, Phase 1 intervention group and stage 2 intervention group patients "pre-medication monitoring serum ferritin and other related iron deficiency indicators", "solvent dose selection" frequency of administration "anemia symptoms improved or anemia-related indicators improved." The coincidence rate of "good" was significantly higher than that of the pre-intervention group. The difference was statistically significant (P0.05); The coincident rate of the patients in the second stage intervention group was significantly higher than that in the first stage intervention group, and the difference was statistically significant (P0.05). The comprehensive rational rate of the second stage intervention group was 77.34%, which was significantly higher than that of the pre-intervention group (41.07%) and the first stage intervention group (47.50%) (P0.05). Conclusion: the DUE standard of Sucrose Iron injection established in our hospital has strong maneuverability and practicability. The effective intervention of clinical pharmacists has solved the problems existing in the course of clinical drug use and promoted the rationality of clinical drug use. It reduces the incidence of adverse drug reactions.
【作者单位】：安徽医科大学附属省立医院药剂科;
【分类号】：R977.6

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