二乙酰大黄酸固体分散体的制备以及体外溶出度的测定

发布时间：2019-03-16 09:23

【摘要】：目的制备二乙酰大黄酸固体分散体,提高其体外溶出性能。方法以聚乙烯吡咯烷酮k30(PVP k30)和泊洛沙姆188(Poloxamer188)为辅料载体,采用研磨法制备二乙酰大黄酸固体分散体,红外测定法和差示扫描量热法对固体分散体进行结构分析。结果二乙酰大黄酸∶PVP k30∶Poloxamer188的最佳比例为2∶1∶1,该条件下制备二乙酰大黄酸固体分散体时,其体外溶出度在30 min达到了90%。差示扫描量热法显示,药物与辅料形成共聚物;红外分析显示,二乙酰大黄酸与两种辅料未形成氢键,结构未发生变化。结论以PVP k30和Poloxamer188为载体制备的固体分散体能够显著提高二乙酰大黄酸的体外溶出度。
[Abstract]:Objective to prepare diacetyl Rhein solid dispersion and improve its dissolution performance in vitro. Methods using polyvinylpyrrolidone k30 (PVP k30) and Poloxamer 188 (Poloxamer188) as excipients, the solid dispersion of diacetyl Rhein was prepared by grinding method. The structure of solid dispersion was analyzed by IR and differential scanning calorimetry (DSC). Results the optimal ratio of diacetyl Rhein to PVP k30:Poloxamer188 was 2? 1? 1?. When the solid dispersion of diacetyl Rhein was prepared under this condition, the in vitro dissolution of diacetyl Rhein reached 90% at 30 min. Differential scanning calorimetry (DSC) showed that the drug formed a copolymer with the excipients, and the infrared analysis showed that the diacetyl Rhein acid did not form hydrogen bond with the two excipients, and the structure did not change. Conclusion solid dispersion based on PVP-k30 and Poloxamer188 can significantly improve the dissolution of diacetyl Rhein in vitro.
【作者单位】：贵州医科大学药学院;
【基金】：贵阳市科技计划项目([2013204]4-4) 2014年贵州省教育厅大学生创新创业(培育)项目(201410660029)
【分类号】：R943

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