促红细胞生成素衍生肽的组织保护作用研究进展
发布时间：2019-04-10 20:34
【摘要】：促红细胞生成素(EPO)因其促进造血功能而广泛用于临床。近年来大量实验证实,大剂量EPO能够通过抗氧化应激、抗凋亡、抗炎症等效应发挥组织保护作用,但会产生血栓及高血压等不良反应,临床效果不佳。而促红细胞生成素衍生肽(HBSP)既保留了EPO的组织保护活性又无EPO的副作用,近年来备受关注。最新报道证实,HBSP通过抗凋亡、抗炎、抗氧化应激对神经系统、心脏、肾脏等发挥多种组织保护作用,具有良好的临床应用前景。
[Abstract]:Erythropoietin (EPO) (Erythropoietin) is widely used in clinic because of its promoting hematopoiesis. In recent years, a large number of experiments have confirmed that high-dose EPO can play a role in tissue protection through anti-oxidative stress, anti-apoptosis, anti-inflammatory effects, but will produce thrombus and hypertension and other adverse reactions, and the clinical effect is not good. Erythropoietin-derived peptide (HBSP) not only preserves the tissue protective activity of EPO but also has no side effects of EPO, which has attracted much attention in recent years. Recent reports confirmed that HBSP can protect the nervous system, heart and kidney by anti-apoptosis, anti-inflammatory and anti-oxidative stress, and has a good clinical application prospect.
【作者单位】： 南方医科大学珠江医院心内科;
【基金】：广东省自然科学基金(10151051501000038;2015A030313238) 广东省医学科学技术研究基金(B2015023)
【分类号】：R96
，
本文编号：2456108
[Abstract]:Erythropoietin (EPO) (Erythropoietin) is widely used in clinic because of its promoting hematopoiesis. In recent years, a large number of experiments have confirmed that high-dose EPO can play a role in tissue protection through anti-oxidative stress, anti-apoptosis, anti-inflammatory effects, but will produce thrombus and hypertension and other adverse reactions, and the clinical effect is not good. Erythropoietin-derived peptide (HBSP) not only preserves the tissue protective activity of EPO but also has no side effects of EPO, which has attracted much attention in recent years. Recent reports confirmed that HBSP can protect the nervous system, heart and kidney by anti-apoptosis, anti-inflammatory and anti-oxidative stress, and has a good clinical application prospect.
【作者单位】： 南方医科大学珠江医院心内科;
【基金】：广东省自然科学基金(10151051501000038;2015A030313238) 广东省医学科学技术研究基金(B2015023)
【分类号】：R96
，
本文编号：2456108
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