雷贝拉唑钠拆分体对大鼠实验性胃溃疡作用的比较研究

发布时间：2019-04-17 07:58

【摘要】：目的:比较雷贝拉唑钠右旋体、左旋体和消旋体对H+,K+-ATP酶活性抑制作用的强弱,以及体内抗实验性大鼠胃溃疡作用的强弱。方法:取正常SD大鼠胃黏膜,体外测定雷贝拉唑钠右旋体、左旋体以及消旋体对H+,K+-ATP酶的抑制作用。建立水应激型、消炎痛刺激、幽门结扎法3种大鼠胃溃疡模型,观察三者对实验性胃溃疡形成的影响。并在水应激模型中取SD大鼠胃黏膜测定体内对H+,K+-ATP酶活性的影响。结果:右旋体、左旋体以及消旋体体外抑制H+,K+-ATP酶的活性未见明显差异;但在水应激模型中体内对H+,K+-ATP酶活性有抑制作用,且雷贝拉唑钠右旋体左旋体和消旋体。与模型组比较,雷贝拉唑钠右旋体对3种SD大鼠实验性胃溃疡具有明显的抑制作用(P0.01或P0.05),效果优于消旋体和左旋体,能显著抑制胃溃疡的发生。结论:体外H+,K+-ATP酶活性抑制测定结果,三者之间抑制效果没有明显差异;但体内酶活性抑制作用雷贝拉唑钠右旋体强于消旋体和左旋体。等剂量雷贝拉唑钠右旋体对3种大鼠胃溃疡的抗溃疡作用强于消旋体和左旋体。
[Abstract]:Aim: to compare the inhibitory effects of Rabeprazole sodium on the activity of H, K-ATP and the anti-gastric ulcer in rats. Methods: the gastric mucosa of normal SD rats was taken to determine the inhibitory effects of Rabeprazole sodium dextrose, levoscele and racemate on H, K-ATP enzyme in vitro. The models of gastric ulcer induced by water stress, indomethacin and pyloric ligation were established in rats, and the effects of these three methods on the formation of experimental gastric ulcer were observed. The effect of SD rat gastric mucosa on the activity of H, K-ATP enzyme was measured in water stress model. Results: there was no significant difference in the activity of H, K-ATP between right-handed, left-handed and racemic bodies in vitro, but the activity of H, K-ATP was inhibited in water stress model in vivo, and the left-hand and racemic bodies of Rabeprazole sodium dextrose and racemate were found to have inhibitory effect on the activity of H, K-ATP in water stress model. Compared with the model group, Rabeprazole sodium dextrose had obvious inhibitory effect on experimental gastric ulcer in three SD rats (P0.01 or P0.05), which was better than racemic body and left-handed body, and could significantly inhibit the occurrence of gastric ulcer. Conclusion: there is no significant difference in inhibition effect of H, K-ATP enzyme activity among them in vitro, but the inhibitory effect of Rabeprazole sodium dextrose in vivo is stronger than racemates and levosomes. The anti-ulcer effect of ribeprazole sodium dextrose on three kinds of gastric ulcer in rats was stronger than that of racemic body and left-handed body in the same dose of Rabeprazole sodium.
【作者单位】：四川抗菌素工业研究所药理学教研室;
【分类号】：R965

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