利巴韦林雾化吸入液的含量测定及体外肺沉积率考察
发布时间：2019-05-11 06:00
【摘要】：目的建立HPLC法测定利巴韦林雾化吸入液中利巴韦林含量的方法,并对其体外沉积率进行考察。方法采用SB-AQ C18色谱柱(250mm×4.6mm,5μm),流动相为水,流速:1.0ml·min~(-1),检测波长:207nm。采用新一代多级药用撞击器测定利巴韦林雾化吸入液的有效部位沉积率。结果在41.6~416μg·ml~(-1)范围内,峰面积对质量浓度有良好的线性关系,日内精密度和日间精密度均2%(n=5);回收率在98%~102%;体外沉积率为68.51%。结论本含量测定方法准确可靠、重复性好,该制剂的体外肺沉积率符合要求。
[Abstract]:Objective to establish a HPLC method for the determination of ribavirin in ribavirin atomized inhalation solution and to investigate its deposition rate in vitro. Methods SB-AQ C18 column (250mm 脳 4.6mm, 5 渭 m) was used, the mobile phase was water, the flow rate was 1.0ml 路min ~ (- 1), and the detection wavelength was 207nm. The deposition rate of effective parts of ribavirin atomized inhaler was determined by a new generation of multistage medicinal impactor. Results in the range of 41.6 渭 g 路ml ~ (- 1), the peak area had a good linear relationship with the mass concentration, the intra-day precision and inter-day precision were 2% (n 鈮，
本文编号：2474296
[Abstract]:Objective to establish a HPLC method for the determination of ribavirin in ribavirin atomized inhalation solution and to investigate its deposition rate in vitro. Methods SB-AQ C18 column (250mm 脳 4.6mm, 5 渭 m) was used, the mobile phase was water, the flow rate was 1.0ml 路min ~ (- 1), and the detection wavelength was 207nm. The deposition rate of effective parts of ribavirin atomized inhaler was determined by a new generation of multistage medicinal impactor. Results in the range of 41.6 渭 g 路ml ~ (- 1), the peak area had a good linear relationship with the mass concentration, the intra-day precision and inter-day precision were 2% (n 鈮，
本文编号：2474296
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