莫西沙星相关性肝损害及血细胞减少的自动监测研究

发布时间：2019-05-28 11:09

【摘要】：目的:利用"住院患者ADE主动监测与智能评估警示系统"分析莫西沙星致肝损害和血细胞减少的发生规律。方法:借助系统回顾性调取我院2016年1 6月期间使用莫西沙星的住院患者病历,设置"肝功能""血小板""血红蛋白""白细胞"四个模块的事件配置器参数,分析系统阳性报警病例及各ADR发生率,并对莫西沙星致肝损害的相关因素进行分析。结果:2263例次莫西沙星用药患者的自动监测,每个模块平均用时约10 min;经临床药师再评估,四个模块阳性报警率分别为54.55%、47.06%、52.94%、47.62%;ADR发生率分别为4.70%、0.54%、3.26%、0.98%。莫西沙星致肝损害在老年患者与非老年患者中无统计学差异,但男性患者比女性患者更容易发生肝损害。结论:专项软件系统可以实现莫西沙星相关性肝损害和血细胞减少等多个ADR的自动监测,筛选速度快,准确率较高;且能够初步预测ADR发生特征和相关因素,有助于降低临床用药风险。
[Abstract]:Objective: to analyze the occurrence of liver damage and hemopenia induced by mosfloxacin by ADE active monitoring and intelligent evaluation warning system in inpatients. Methods: with the help of system, the medical records of inpatients who were used in our hospital during January to June 2016 were collected retrospectively. the event configuration parameters of four modules of "liver function", "platelet", "hemoglobin" and "white blood cell" were set up. The positive alarm cases and the incidence of ADR were analyzed, and the related factors of liver damage induced by mosifloxacin were analyzed. Results: 2263 patients were monitored automatically. The average duration of each module was about 10 min;. The positive alarm rates of the four modules were 54.55%, 47.06%, 52.94% and 47.62%, respectively. the positive alarm rates of the four modules were 54.55%, 47.06%, 52.94% and 47.62%, respectively. The incidence of ADR was 4.70%, 0.54%, 3.26% and 0.98% respectively. There was no significant difference in liver damage between elderly patients and non-elderly patients, but liver damage was more likely in male patients than in female patients. Conclusion: the special software system can realize the automatic monitoring of many ADR, such as mosifloxacin associated liver damage and hemopenia, and the screening speed is fast and the accuracy is high. It can predict the occurrence characteristics and related factors of ADR, which is helpful to reduce the risk of clinical drug use.
【作者单位】：解放军总医院药品供应中心;
【基金】：2014年全军后勤科研重点项目(BWS14R039)
【分类号】：R978.1

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