药物制剂中月桂醇磷酸酯钾的新型处理方法及对水溶性药物成分表征的影响

发布时间：2019-05-28 19:28

【摘要】：目的:建立一种新型、简便的方法处理药物制剂中的月桂醇磷酸酯钾(HR-S1),并对其中的水溶性药物成分进行含量表征。方法:取润肤霜2.0g,加入甲醇10 mL,搅拌,过滤,加甲醇5 mL洗涤残渣,合并滤液;加入0.25 mL磷酸,摇匀,用10 mL正己烷萃取,重复3次,去除正己烷层,残余溶液氮吹至干,加甲醇复溶。润肤霜中人参皂苷Rg1的检测:C18色谱柱为固定相,乙腈-0.1%醋酸梯度洗脱,检测波长为203 nm。结果 :本研究所建立的方法能完全去除HR-S1对润肤霜中水溶性药物成分人参皂苷含量表征的干扰,方法回收率高至99.6%,精密度和重复性好。结论:该方法操作简便快速,能完全消除HR-S1的干扰,回收率高,可用于乳霜中月桂醇磷酸酯钾的去除及人参皂苷Rg1的表征。
[Abstract]:Objective: to establish a new and simple method for the treatment of potassium lauryl phosphate (HR-S1) in pharmaceutical preparations and to characterize the content of water-soluble drugs. Methods: 2.0 g moisturizing cream was taken, 10 mL, methanol was added to stir, filter, methanol 5 mL was added to wash the residue, and the filtrate was combined. Add 0.25 mL phosphate, shake well, extract with 10 mL n-hexane, repeat 3 times, remove n-hexane layer, blow nitrogen into dry solution and redissolve with methanol. Determination of ginsenosides Rg1 in moisturizer: C _ (18) column was used as stationary phase, acetonitrile-0.1% acetic acid gradient eluted, and the detection wavelength was 203 nm.. Results: the method established in this study can completely remove the interference of HR-S1 on the characterization of ginsenosides in moisturizer. The recovery rate of the method is as high as 99.6%, and the precision and reproducibility are good. Conclusion: the method is simple and rapid, can completely eliminate the interference of HR-S1, and has high recovery. It can be used for the removal of potassium lauryl phosphate from cream and the characterization of ginsenosides Rg1.
【作者单位】：河北医科大学药学院;
【分类号】：R927.2

【相似文献】