硝酸依柏康唑的合成新方法
发布时间：2019-06-03 09:52
【摘要】：标题化合物是一种外用广谱抗真菌感染药物,以邻苯二甲酸酐和3,5-二氯苯乙酸为原料,首先经缩合、催化加氢、环合3步反应制备得到关键中间体2,4-二氯-10,11-二氢-5H-二苯并[a,d]环庚烯-5-酮,然后经还原、氯化、N-烃基化、成盐等4步反应制备得到。该合成方法缩短了标题化合物的合成路线,提高了总收率,不产生有机磷废弃物,更适于工业化生产。
[Abstract]:The title compound is a broad-spectrum antifungal drug for external use. Phthalic anhydride and 3,5-dichlorophenylacetic acid are used as raw materials. The key intermediate 2, 4-dichloro-10, 11-dihydro-5H-dibenzo [a, d] cycloheptene-5-one was prepared by three-step cyclization, and then prepared by reduction, chlorination, N-alkylation and salt formation. The synthesis method shortens the synthesis route of the title compound, improves the total yield, does not produce organophosphorus waste, and is more suitable for industrial production.
【作者单位】： 苏州健雄职业技术学院生物与化学工程系;
【基金】：江苏省高校“青蓝工程”资助项目 太仓市科学技术局项目(TC2014GY19)
【分类号】：R914.5
，
本文编号：2491859
[Abstract]:The title compound is a broad-spectrum antifungal drug for external use. Phthalic anhydride and 3,5-dichlorophenylacetic acid are used as raw materials. The key intermediate 2, 4-dichloro-10, 11-dihydro-5H-dibenzo [a, d] cycloheptene-5-one was prepared by three-step cyclization, and then prepared by reduction, chlorination, N-alkylation and salt formation. The synthesis method shortens the synthesis route of the title compound, improves the total yield, does not produce organophosphorus waste, and is more suitable for industrial production.
【作者单位】： 苏州健雄职业技术学院生物与化学工程系;
【基金】：江苏省高校“青蓝工程”资助项目 太仓市科学技术局项目(TC2014GY19)
【分类号】：R914.5
，
本文编号：2491859
本文链接：https://www.wllwen.com/yixuelunwen/yiyaoxuelunwen/2491859.html
最近更新
教材专著
